{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:05:49Z","timestamp":1768259149004,"version":"3.49.0"},"reference-count":4,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T00:00:00Z","timestamp":1100649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T00:00:00Z","timestamp":1100649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Recurrent hyperparathyroidism (HPT) after total parathyroidectomy (TPTX) in chronic renal failure appears more common than might be anticipated. &lt;i&gt;Methods:&lt;\/i&gt; To study its predictors, we reviewed all 20 cases of TPTX performed at our hospital in a 10-year period. &lt;i&gt;Results:&lt;\/i&gt; During follow-up (median 46.8 months (range 9.3\u2013120.3)), 15 patients had measurable PTH levels (&gt;10 pg\/ml), 7 had levels above the normal range (recurrent HPT), and 3 had PTH levels &gt;300 pg\/ml (severe recurrent HPT). Total follow-up post-TPTX was equal in those who developed recurrent HPT and others, but those with recurrent HPT had spent longer on dialysis post-TPTX (61.9 \u00b1 34.9 vs. 21.8 \u00b1 12.0 months; p = 0.001). Patients with recurrent HPT required less vitamin D supplementation during the 10 days post-TPTX (p = 0.025). Log [maximal PTH post-TPTX] correlated with duration of dialysis dependency post-TPTX (r = 0.591, p = 0.006), lowest serum calcium level during the first 30 days post-TPTX (r = 0.449, p = 0.047), and mean serum calcium during the first 30 days post-TPTX (r = 0.546, p = 0.013). Mean log [maximal PTH post-TPTX] was significantly lower in patients with ectopic calcification (p = 0.047). In multiple regression analysis, duration of dialysis post-TPTX and lowest serum calcium level during the first 30 days post-TPTX were the only independent predictors of log [maximal PTH post-TPTX]. &lt;i&gt;Conclusion:&lt;\/i&gt; Recurrent HPT is common following TPTX and predicted by duration of dialysis dependency post-TPTX, a measure of overall exposure to the uraemic stimulus to parathyroid hyperplasia, and the degree of early hypocalcaemia, possibly reflecting the adequacy of operative parathyroid ablation.<\/jats:p>","DOI":"10.1159\/000073014","type":"journal-article","created":{"date-parts":[[2003,10,6]],"date-time":"2003-10-06T10:00:52Z","timestamp":1065434452000},"page":"c15-c22","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of Recurrent Hyperparathyroidism after Total Parathyroidectomy in Chronic Renal Failure"],"prefix":"10.1159","volume":"95","author":[{"given":"Jon","family":"Stratton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Simcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Farrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000013520"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000057440"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.4.1840"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200105000-00020"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/73014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/73014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:46:17Z","timestamp":1745466377000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000073014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,17]]},"references-count":4,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000073014","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,17]]}}}