{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:07:20Z","timestamp":1759032440307,"version":"3.40.4"},"reference-count":3,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; To analyze how far an ischemic component might have been involved in optic neuritis. &lt;i&gt;Methods:&lt;\/i&gt; Case report: a 32-year-old man with symptoms characteristic for optic neuritis underwent extensive clinical, laboratory\/serological and vascular examination for systemic associations and vascular involvement. &lt;i&gt;Results:&lt;\/i&gt; The patient was found to have a temporary ocular blood flow dysregulation and increased plasma endothelin-1 levels which decreased after the acute phase of the optic nerve. &lt;i&gt;Conclusions:&lt;\/i&gt; We conclude that there might be an ischemic component in this patient with optic neuritis and hypothesize that this ischemic component is at least in part due to a temporarily increased endothelin-1 level.<\/jats:p>","DOI":"10.1159\/000073079","type":"journal-article","created":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T08:54:20Z","timestamp":1066985660000},"page":"451-453","source":"Crossref","is-referenced-by-count":15,"title":["Transient Raise of Endothelin-1 Plasma Level and Reduction of Ocular Blood Flow in a Patient with Optic Neuritis"],"prefix":"10.1159","volume":"217","author":[{"given":"Timo","family":"Haufschild","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidney G.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedwig J.","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Flammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.7.687.5065"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(00)00028-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200103000-00011"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/73079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/73079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:46:50Z","timestamp":1745466410000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000073079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":3,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2003,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000073079","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"type":"print","value":"0030-3755"},{"type":"electronic","value":"1423-0267"}],"subject":[],"published":{"date-parts":[[2003]]}}}