{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:07:19Z","timestamp":1792678039895,"version":"4.5.0"},"reference-count":6,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; The purpose of this study was to compare complications and outcome of preterm neonates weighing \u22641,500 g who developed necrotizing enterocolitis (NEC) to neonates without NEC. &lt;i&gt;Study Design:&lt;\/i&gt; During January, 1995 to December, 1998, 211 live preterm neonates were born with birth weight \u22641,500 g. A cross sectional prospective study was designed and two groups were defined: 17 neonates who developed NEC and 194 without NEC. Multiple logistic regression analysis was performed to determine independent risk factors for the development of NEC. &lt;i&gt;Results:&lt;\/i&gt; The prevalence of NEC was 8% (17\/211). The following complications were found to be significantly higher among mothers of neonates with NEC: mild pre-eclampsia (11.8 vs. 2.6%, p = 0.04); severe pre-eclampsia (35.5 vs. 12.9%, p = 0.01); chronic hypertension (29.4 vs. 5.7%, p &lt; 0.001) and low birth weight (968 \u00b1 233 vs. 1,123 \u00b1 257 g, p = 0.02). In contrast, mean maternal age, mean gestational age at delivery and parity were not significantly different between the groups. A multivariate analysis including the following factors: maternal hypertensive disorders, pregestational diabetes mellitus, birth weight and gestational age at delivery, found only maternal hypertensive disorders to be independent risk factors for NEC (OR = 5.21, 95% CI 1.64\u201316.58). &lt;i&gt;Conclusions:&lt;\/i&gt; Maternal hypertension is an independent risk factor for the development of NEC in preterm neonates weighing &lt;1,500 g. Thus, maternal vascular disorders may play an important role in the pathophysiology of NEC.<\/jats:p>","DOI":"10.1159\/000073132","type":"journal-article","created":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T08:54:20Z","timestamp":1066985660000},"page":"404-407","source":"Crossref","is-referenced-by-count":40,"title":["Maternal Hypertensive Disorders Are an Independent Risk Factor for the Development of Necrotizing Enterocolitis in Very Low Birth Weight Infants"],"prefix":"10.1159","volume":"18","author":[{"given":"Asher","family":"Bashiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Zmora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reli","family":"Hershkovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Shoham-Vardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Mazor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2003,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90599-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90264-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)80002-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0792"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.32882"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.32882"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/73132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/73132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:47:21Z","timestamp":1745466441000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000073132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":6,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2003,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000073132","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}