{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:24:02Z","timestamp":1775240642271,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>High numbers of serotonin transporter (SERT) binding sites and high serotonin (5-HT) content are expressed in the adrenal medulla of wild-type (SERT+\/+) mice. Acute restraint stress increases adrenomedullary 5-HT, norepinephrine (NE) and epinephrine (E) release, adrenomedullary tyrosine hydroxylase (TH) mRNA, and angiotensin II AT&lt;sub&gt;2&lt;\/sub&gt; receptor expression. There are no alterations in adrenal catecholamine content during restraint. In littermate SERT\u2013\/\u2013 mice, which do not express SERT binding sites, the basal adrenomedullary 5-HT content is significantly reduced and does not increase after stress. The stress-induced increase in plasma E is higher in SERT\u2013\/\u2013 than in SERT+\/+ animals. In SERT\u2013\/\u2013 mice, the stress-induced increase in expression of TH mRNA does not occur, and as a consequence, adrenal E content decreases, and adrenal E and NE content are lower than that of SERT+\/+ mice during restraint. In addition, instead of increased expression, stress induces a profound decrease in the number of adrenomedullary AT&lt;sub&gt;2&lt;\/sub&gt; receptors in SERT\u2013\/\u2013 mice. Our results indicate that SERT is necessary for the stress-induced increase in adrenomedullary catecholamine synthesis and AT&lt;sub&gt;2&lt;\/sub&gt; receptor expression. These data further indicate a close relationship between the adrenomedullary 5-HT and angiotensin II systems, and an important role of adrenomedullary AT&lt;sub&gt;2&lt;\/sub&gt; receptors in catecholamine synthesis and release during stress.<\/jats:p>","DOI":"10.1159\/000073705","type":"journal-article","created":{"date-parts":[[2003,10,31]],"date-time":"2003-10-31T15:06:34Z","timestamp":1067612794000},"page":"217-225","source":"Crossref","is-referenced-by-count":21,"title":["The Serotonin Transporter is Required for Stress-Evoked Increases in Adrenal Catecholamine Synthesis and Angiotensin II AT&lt;sub&gt;2&lt;\/sub&gt; Receptor Expression"],"prefix":"10.1159","volume":"78","author":[{"given":"I.","family":"Armando","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.A.","family":"Tjurmina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.L.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Saavedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5292.1527"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.6.539"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1997.0619"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00566-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.10.5001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007683810230"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220416"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(85)90055-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(86)90053-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.9.3880"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00023-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-0019"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2000.0678"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00614-V"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90408-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-78-12-967"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00169-1"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/73705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/73705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:45:48Z","timestamp":1745466348000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000073705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000073705","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}