{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:10:19Z","timestamp":1763035819326,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The wide variation in the detection of herpes simplex virus (HSV) DNA (36\u201375%) by polymerase chain reaction (PCR) in erythema multiforme (EM) may be partly attributed to differences in case selection in terms of subsets of EM studied. &lt;i&gt;Objective:&lt;\/i&gt; To determine the frequencies of detection of HSV DNA in specific subsets of EM. &lt;i&gt;Methods:&lt;\/i&gt; Nested PCR was used to detect HSV DNA in skin biopsies with histologically proven EM. &lt;i&gt;Results:&lt;\/i&gt; PCR was performed on skin biopsies from 63 patients with EM. HSV DNA was detected in 3\/11 (27.2%) of single-episode HSV-associated EM (HAEM), 6\/10 (60%) of recurrent HAEM, 1\/4 (25%) of single-episode idiopathic EM and 6\/12 (50%) of recurrent idiopathic EM. HSV DNA was not detected in atypical EM (0\/11), suspected drug-induced EM (0\/9) or Stevens-Johnson syndrome (0\/6). &lt;i&gt;Conclusion:&lt;\/i&gt; The overall PCR positive rates of HAEM (42.9%) and idiopathic EM (43.8%) were comparable suggesting that idiopathic EM is likely to be related to a subclinical HSV infection.<\/jats:p>","DOI":"10.1159\/000074112","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T09:25:47Z","timestamp":1071825947000},"page":"349-353","source":"Crossref","is-referenced-by-count":68,"title":["Detection of Herpes simplex Virus Genomic DNA in Various Subsets of Erythema multiforme by Polymerase Chain Reaction"],"prefix":"10.1159","volume":"207","author":[{"given":"Patricia P.L.","family":"Ng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Jiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiok Hee","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suat Hoon","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277397"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12495372"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12336800"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277232"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90732-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750011192"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000018000"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000018121"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000051776"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:49:31Z","timestamp":1745466571000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000074112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000074112","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2003]]}}}