{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:29:13Z","timestamp":1766179753940,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Psoriasis features an increased level and activity of tumor necrosis factor \u03b1 (TNF-\u03b1). The TNF-\u03b1 gene has single nucleotide polymorphisms (SNPs) at positions \u2013308 (\u2013308G&gt;A) and \u2013238 (\u2013238G&gt;A) in the promoter region, and the \u2013238G&gt;A SNP has been reported to be associated with psoriasis vulgaris (PV) and psoriatic arthritis in Caucasians. &lt;i&gt;Objective:&lt;\/i&gt; To examine whether these SNPs are associated with susceptibility to PV in Japanese patients, we investigated the genotype and allele frequencies at each SNP in Japanese PV patients and in controls. &lt;i&gt;Methods:&lt;\/i&gt; We examined 163 PV patients and 96 healthy individuals. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. &lt;i&gt;Results:&lt;\/i&gt; No significant association between the genotypes or alleles of these SNPs and susceptibility to PV was observed. &lt;i&gt;Conclusion: &lt;\/i&gt;These SNPs themselves are not associated with susceptibility to PV in the Japanese.<\/jats:p>","DOI":"10.1159\/000074117","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T09:25:47Z","timestamp":1071825947000},"page":"371-374","source":"Crossref","is-referenced-by-count":22,"title":["Lack of Association between the Promoter Polymorphisms at Positions \u2013308 and \u2013238 of the Tumor Necrosis Factor Alpha Gene and Psoriasis vulgaris in Japanese Patients"],"prefix":"10.1159","volume":"207","author":[{"given":"Yuichiro","family":"Tsunemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Nishibu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritaka","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Mitsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayoi","family":"Tada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideshi","family":"Torii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Asahina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.530203.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12337469"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00001.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371679"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.2.557"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00654.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.0202a-5.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00022-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480361"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(96)00518-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00242-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540505.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:49:38Z","timestamp":1745466578000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000074117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000074117","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2003]]}}}