{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:12:57Z","timestamp":1775815977799,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; To investigate the metabolic effects of recombinant human growth hormone (rhGH) in an Alstr\u00f6m syndrome patient with growth hormone deficiency. &lt;i&gt;Methods:&lt;\/i&gt; A 15-year-old Alstr\u00f6m syndrome boy with growth hormone deficiency received rhGH therapy for 1 year. Biochemical parameters, including hepatic enzyme levels, lipid profiles, and insulin sensitivity, were measured. Body composition analysis and computed tomography scans of the liver were performed. &lt;i&gt;Results:&lt;\/i&gt; After 1 year of rhGH treatment, body fat mass, fat infiltration in the liver, and serum lipid profiles had all decreased. Insulin sensitivity and acanthosis nigricans improved. &lt;i&gt;Conclusion:&lt;\/i&gt; rhGH therapy might have beneficial effects on body composition, liver fat content, lipid profiles, and insulin resistance in Alstr\u00f6m syndrome patients, with improvement of the glucose homeostasis.<\/jats:p>","DOI":"10.1159\/000074248","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T09:25:47Z","timestamp":1071825947000},"page":"297-301","source":"Crossref","is-referenced-by-count":13,"title":["Metabolic Effects of Growth Hormone Therapy in an Alstr\u00f6m Syndrome Patient"],"prefix":"10.1159","volume":"60","author":[{"given":"Tsai-Sung","family":"Tai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne Huey-Herng","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050887"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/ng979"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971212)73:2<150::AID-AJMG9>3.0.CO;2-Y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.4.1407"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.7.2076"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.3.727"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1412"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.10.3285"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(02)00004-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80288-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00138-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00502.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00460.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970303)69:1<13::AID-AJMG3>3.3.CO;2-F"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:51:21Z","timestamp":1745466681000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000074248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":14,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000074248","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}