{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:48:19Z","timestamp":1774622899190,"version":"3.50.1"},"reference-count":5,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2003,12,5]],"date-time":"2003-12-05T00:00:00Z","timestamp":1070582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,12,5]],"date-time":"2003-12-05T00:00:00Z","timestamp":1070582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To determine whether all patients with undetectable unconjugated estriol (uE3) on multiple marker screening (MMS) are carriers for steroid sulfatase (STS) deficiency. &lt;i&gt;Methods:&lt;\/i&gt; This is a retrospective review of 65 pregnancies with undetectable uE3 on MMS. &lt;i&gt;Results:&lt;\/i&gt; Of the 65 pregnancies, there were 21 that continued, 40 spontaneous losses, 2 lost to follow-up and 2 elective terminations. Of the 21 continuing pregnancies, 15 were determined to be carriers of the STS deletion. Twenty-seven of the 40 pregnancy losses were associated with elevated alpha-fetoprotein (AFP); about half of the losses were shown to have occurred prior to sampling. &lt;i&gt;Conclusion:&lt;\/i&gt; Patients with undetectable uE3 are likely to be carriers of the STS deletion, except those with associated elevated AFP. Elevated AFP with undetectable uE3 on MMS is a marker of preexisting or impending fetal demise.<\/jats:p>","DOI":"10.1159\/000074259","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T09:25:47Z","timestamp":1071825947000},"page":"43-48","source":"Crossref","is-referenced-by-count":8,"title":["Association of Undetectable Unconjugated Estriol on Multiple Marker Screening with Steroid Sulfatase Deficiency"],"prefix":"10.1159","volume":"19","author":[{"given":"Shama D.","family":"Jari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luanne M.","family":"Fraer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Allen","family":"Hogge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(82)90085-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199603000-00024"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00289-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91343-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(97)06552-2"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:51:42Z","timestamp":1745466702000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000074259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,5]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000074259","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,5]]}}}