{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:38:02Z","timestamp":1771666682432,"version":"3.50.1"},"reference-count":3,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Evidence indicates that eradication of &lt;i&gt;Helicobacter pylori&lt;\/i&gt; leads to the disappearance of hyperplastic polyps in the stomach. However, there are some exceptions. We have compared endoscopic and serologic findings of responder and non-responder cases with hyperplastic polyps to try to identify the cause(s), other than &lt;i&gt;H. pylori&lt;\/i&gt; infection, of the formation or growth of gastric hyperplastic polyps. &lt;i&gt;Methods:&lt;\/i&gt; We retrospectively studied 33 patients whose hyperplastic polyps disappeared after eradication of &lt;i&gt;H. pylori&lt;\/i&gt; and 10 patients whose hyperplastic polyps did not disappear after eradication. The patients were examined both endoscopically and serologically before, 1\u20133 months after and 12\u201315 months after the eradication. &lt;i&gt;Results:&lt;\/i&gt; The responder and non-responder groups were similar with respect to age, sex, coexisting diseases, and histologic findings. The number and maximum size of polyps tended to be larger before treatment in the non-responder group than in the responder group. The serum gastrin level was higher in the non-responder group than in the responder group before, 1\u20133 months after and 12\u201315 months after the eradication (p = 0.0096, p &gt; 0.2, p = 0.0014). On histologic examination, similar reductions in the degree of inflammatory cell infiltration in the gastric mucosa of the antrum and body were seen in both the responder and non-responder groups. In the non-responders, the size and numbers of the polyps regressed in 5 of the 10 patients. The score of glandular atrophy in the antrum and the serum gastrin levels in the non-regressed cases was higher than those in the regressed cases at 1\u20133 and 12\u201315 months after eradication. &lt;i&gt;Conclusion:&lt;\/i&gt; Persistent high gastrin levels were found in the non-responder cases with gastric hyperplastic polyps.<\/jats:p>","DOI":"10.1159\/000074516","type":"journal-article","created":{"date-parts":[[2003,10,31]],"date-time":"2003-10-31T15:06:34Z","timestamp":1067612794000},"page":"57-62","source":"Crossref","is-referenced-by-count":37,"title":["Endoscopic, Histological and Serologic Findings of Gastric Hyperplastic Polyps after Eradication of &lt;i&gt;Helicobacter pylori&lt;\/i&gt;: Comparison between Responder and Non-Responder Cases"],"prefix":"10.1159","volume":"68","author":[{"given":"Toshifumi","family":"Ohkusa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Tanizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Asaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Terai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Ohkura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90058-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(01)02705-8"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:53:32Z","timestamp":1745466812000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000074516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":3,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000074516","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}