{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:03:03Z","timestamp":1778976183027,"version":"3.51.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>A number of growth factors, their binding proteins, and their receptors have been shown to be induced in the hypoxic-ischemic (HI) brain. In this prospective study, we aimed at determining the levels of insulin-like growth factor 1 (IGF-1), growth hormone (GH), and cortisol in HI babies and at identifying whether they differ from the levels of control infants. The serum IGF-1 levels were measured after the first 12\u201324 h of life, and the measurements were repeated on the 5th and 10th days of life for babies with HI encephalopathy (n = 18) and on the 10th day of life for controls (n = 19). Blood samples for measurement of cortisol and GH from both HI and control groups were collected after the first 12\u201324 h of life. There were 11 babies in the mild-to-moderate (stages I and II) group and 7 babies in the severe (stage III) group according to Sarnat and Sarnat. The IGF-1 levels of the HI group measured after 12\u201324 h [78.5 \u00b1 27.9 (range 9\u2013123.4) ng\/ml] and on the 10th day [72.2 \u00b1 36.8 (range 29.7\u2013159.2) ng\/ml] of life were statistically significantly lower than the IGF-1 levels of the control group [121.5 \u00b1 50.4 (range 74.4\u2013280.5) ng\/ml and 133.1 \u00b1 34.4 (range 65.9\u2013202) ng\/ml, respectively] (p = 0.002 and p = 0.001, respectively). But there was no statistically significant difference between mild-to-moderate HI group and severe HI group in terms of IGF-1 levels after 12\u201324 h and 5 and 10 days of life (p &gt; 0.05). Also there was no statistically significant difference in IGF-1 values after the first 12\u201324 h and after 10 days of life between HI subjects who died or survived (p &gt; 0.05). The GH levels of the HI group after the first 12\u201324 h of life [34.6 \u00b1 32.3 (range 0.1\u2013120) mIU\/l] were statistically significantly higher than those in the control group [10.4 \u00b1 4.5 (range 3.7\u201316.9) mIU\/l] (p = 0.005). There was no statistically significant difference in the serum cortisol levels between HI and control groups after the first 12\u201324 h of life [18.7 \u00b1 17.0 (range 1.6\u201365.1) \u00b5g\/dl vs. 10.8 \u00b1 5.4 (range 3.0\u201323.2) \u00b5g\/dl] (p &gt; 0.05). No statistically significant correlation was found between IGF-1 levels and GH and cortisol levels of the HI encephalopathy group [r = \u20130.113 (p &gt; 0.05) and r = 0.108 (p &gt; 0.05), respectively]. In conclusion, this study showed decreased levels of serum IGF-1 and increased levels of GH which may be secondary to serum IGF-1 influx from the circulation to the brain as a protective mechanism or may be due to some cytokines which alter the GH\/IGF axis, inhibit the action of IGF-1, and stimulate IGF-binding protein 1.<\/jats:p>","DOI":"10.1159\/000074952","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T09:25:47Z","timestamp":1071825947000},"page":"15-20","source":"Crossref","is-referenced-by-count":11,"title":["Serum Insulin-Like Growth Factor 1 and Growth Hormone Levels of Hypoxic-Ischemic Newborns"],"prefix":"10.1159","volume":"85","author":[{"given":"Mehmet","family":"Satar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"\u00d6zcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hacer","family":"Yap\u0131c\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nejat","family":"Narl\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(93)90191-Q"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90425-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03148-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90089-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90931-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90531-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00051-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/en.135.5.1753"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.10.4153"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000046146"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/74952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:57:19Z","timestamp":1745467039000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000074952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000074952","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}