{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:10:38Z","timestamp":1791900638702,"version":"4.3.4"},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1159\/000074972","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T09:25:47Z","timestamp":1071825947000},"page":"445-456","source":"Crossref","is-referenced-by-count":13,"title":["Acute pancreatitis possible initial triggering mechanism and prophylaxis"],"prefix":"10.1016","volume":"3","author":[{"given":"Laura Iris","family":"Cosen-Binker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Gustavo","family":"Binker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Negri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Tiscornia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1159\/000074972_bib1","first-page":"353","article-title":"Some aspects of human and canine macroscopic pancreas innervation","volume":"66","author":"Tiscornia","year":"1976","journal-title":"Am J Gastroenterol"},{"key":"10.1159\/000074972_bib2","first-page":"57","article-title":"S\u00edntesis conceptual de la inervaci\u00f3n macroscopica gastro-duodeno-pancre\u00e1tica","volume":"23","author":"Tiscornia","year":"1993","journal-title":"Ac Ge La"},{"key":"10.1159\/000074972_bib3","first-page":"29","article-title":"Relaci\u00f3n funcional antro-duodeno pancre\u00e1tica. Parte I","volume":"3","author":"Cosen","year":"1971","journal-title":"Acta Gastroenterol Latinoam"},{"key":"10.1159\/000074972_bib4","first-page":"93","article-title":"Relaci\u00f3n funcional antro-duodeno pancre\u00e1itica. Parte II","volume":"3","author":"Cosen","year":"1971","journal-title":"Acta Gastroenterol Latinoam"},{"key":"10.1159\/000074972_bib5","first-page":"26","article-title":"Neurology and neuropathology of the pancreatic innervation. JOP","volume":"3","author":"Salvioli","year":"2002","journal-title":"Pancreas Online J"},{"key":"10.1159\/000074972_bib6","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1023\/A:1018887704337","article-title":"Diagnostic relevance on interleukin pattern and acute-phase proteins in early phase of post-ERCP pancreatitis","volume":"43","author":"Oezcueruemez-Porsch","year":"1998","journal-title":"Dig Dis Sci"},{"key":"10.1159\/000074972_bib7","first-page":"7","article-title":"Peut-on pr\u00e9venis la pancr\u00e9atite aigu\u00eb apres cath\u00e9t\u00e9risme endoscopique bilio-pancr\u00e9atique?","volume":"8","author":"Beauchant","year":"2001","journal-title":"Hepatogastro"},{"key":"10.1159\/000074972_bib8","first-page":"2120","article-title":"Clinical outcome of post-ERCP pancreatitis: Relationship to history of previous pancreatitis","volume":"90","author":"Chen","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"10.1159\/000074972_bib9","first-page":"557","article-title":"Pancreatitis secondary to percutaneous liver biopsy-associated hemobilia","volume":"91","author":"Van Os","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1159\/000074972_bib10","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00006676-199105000-00013","article-title":"ERCP and endoscopic sphincterotomy-induced pancreatitis","volume":"6","author":"Sherman","year":"1991","journal-title":"Pancreas"},{"key":"10.1159\/000074972_bib11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/gut.37.3.434","article-title":"Vasoactive mediators and the progression from oedematous to necrotizing experimental acute pancreatitis","volume":"37","author":"Weidenbach","year":"1995","journal-title":"Gut"},{"key":"10.1159\/000074972_bib12","first-page":"113","article-title":"Hemodynamic Disorders, Thrombosis and Shock","volume":"6","year":"1999"},{"key":"10.1159\/000074972_bib13","first-page":"1773","article-title":"Mediators of ischemia-reperfusion injury of rat lung","volume":"150","author":"Eppinger","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1159\/000074972_bib14","first-page":"2736","article-title":"Oxidative stress in acute pancreatitis","volume":"46","author":"Schulz","year":"1999","journal-title":"Hepato-Gastroenterology"},{"key":"10.1159\/000074972_bib15","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1023\/A:1018886120711","article-title":"Tissue-specific cytokine production during experimental acute pancreatitis: A probable mechanism for distant organ dysfunction","volume":"42","author":"Norman","year":"1997","journal-title":"Dig Dis Sci"},{"key":"10.1159\/000074972_bib16","first-page":"9","article-title":"Physiopathologie de l\u2019inflammation pancr\u00e9atique au cours de la pancr\u00e9atite aigu\u00eb","volume":"6","author":"Dagorn","year":"1999","journal-title":"Hepatogastro"},{"key":"10.1159\/000074972_bib17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF02805224","article-title":"Pulmonary infiltrations sign of severe acute pancreatitis","volume":"19","author":"Lankisch","year":"1996","journal-title":"Int J Pancreatol"},{"key":"10.1159\/000074972_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/A:1022399824880","article-title":"Leukotriene generation and neutrophil infiltration after experimental acute pancreatitis","volume":"22","author":"Folch","year":"1998","journal-title":"Inflammation"},{"key":"10.1159\/000074972_bib19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00006676-199804000-00017","article-title":"Acute pancreatitis and cytokines, \u2018second attack\u2019 by septic complication leads to organ failure","volume":"16","author":"Ogawa","year":"1998","journal-title":"Pancreas"},{"key":"10.1159\/000074972_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF02788564","article-title":"The effects of neutrophil depletion on a completely non-invasive model of acute pancreatitis associated lung injury","volume":"24","author":"Bhatia","year":"1998","journal-title":"Int J Pancreatol"},{"key":"10.1159\/000074972_bib21","first-page":"164","article-title":"Pancr\u00e9atite aigu\u00eb: nouvelles donn\u00e9es physiopathologiques","volume":"25","author":"Frossard","year":"2001","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1159\/000074972_bib22","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/gut.29.6.782","article-title":"Fatal acute pancreatitis","volume":"29","author":"Wilson","year":"1988","journal-title":"Gut"},{"key":"10.1159\/000074972_bib23","series-title":"Experimental and Surgical Techniques in the Rat","first-page":"276","article-title":"Specific surgical operations-pancreatectomy","year":"1994"},{"key":"10.1159\/000074972_bib24","series-title":"Gastrointestinal Disease","first-page":"1415","article-title":"Anatomy, embryology and developmental anomalies","author":"Ermak","year":"1983"},{"key":"10.1159\/000074972_bib25","first-page":"57","article-title":"Conceptual synthesis of macroscopic gastroduodeno-pancreatic innervation based on an anatomic study in the rat","volume":"23","author":"Tiscornia","year":"1993","journal-title":"Ac Ge La"},{"key":"10.1159\/000074972_bib26","first-page":"366","article-title":"Neural control of the exocrine pancreas: An analysis of the cholinergic, adrenergic and peptidergic pathways and their positive and negative components. 1. Integration of neural and hormonal mechanisms","volume":"54","author":"Tiscornia","year":"1987","journal-title":"Mt Sinai J Med"},{"key":"10.1159\/000074972_bib27","first-page":"126","article-title":"Neural control of the exocrine pancreas: An analysis of the cholinergic, adrenergic and peptidergic pathways and their positive and negative components. 2. Integretion of neural and hormonal mechanisms","volume":"55","author":"Tiscornia","year":"1988","journal-title":"Mt Sinai J Med"},{"key":"10.1159\/000074972_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02788375","article-title":"The effect of chronic intraperitoneal infusion of bacteria endotoxin on exocrine pancreas function in rats","volume":"19","author":"Vaccaro","year":"1996","journal-title":"Int J Pancreatol"},{"key":"10.1159\/000074972_bib29","first-page":"541","article-title":"The neural control of exocrine and endocrine pancreas","volume":"67","author":"Tiscornia","year":"1977","journal-title":"Am J Gastroenterol"},{"key":"10.1159\/000074972_bib30","first-page":"494","article-title":"Role of autonomous nervous system and disruption of entero-pancreatic-feedback","volume":"85","author":"Tiscornia","year":"1998","journal-title":"Pren Med Arg"},{"key":"10.1159\/000074972_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1159\/000074972_bib32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0278-6915(94)90175-9","article-title":"Myeloperoxidase as a biomarker of skin irritation and inflammation","volume":"32","author":"Trush","year":"1994","journal-title":"Food Chem Toxicol"},{"issue":"suppl","key":"10.1159\/000074972_bib33","first-page":"S248","article-title":"Myelo-peroxidase (MPO) activity: A correlation with the inflammation degree in an experimental model of acute pancreatitis in the rat","volume":"39","author":"Negri","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"10.1159\/000074972_bib34","series-title":"Statistical Principles in Experimental Design","author":"Winer","year":"1991"},{"key":"10.1159\/000074972_bib35","doi-asserted-by":"crossref","first-page":"22417","DOI":"10.1074\/jbc.270.38.22417","article-title":"Pancreatitis-associated protein I (PAP-I), an acute phase protein induced by cytokines","volume":"270","author":"Dussetti","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1159\/000074972_bib36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000201127","article-title":"The acute phase reaction of the exocrine pancreas","volume":"55","author":"Keim","year":"1994","journal-title":"Digestion"},{"key":"10.1159\/000074972_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000055791","article-title":"Pancreatitis-associated protein levels in pancreatic juice from patients with pancreatic diseases","volume":"1","author":"Motoo","year":"2001","journal-title":"Pancreatology"},{"key":"10.1159\/000074972_bib38","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/00003246-199805000-00024","article-title":"Acute-phase response of the rat pancreas protects against further aggression with severe necrotizing pancreatitis","volume":"26","author":"Friedler","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1159\/000074972_bib39","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/0016-5085(95)90439-5","article-title":"The sympathetic nervous system modulates perception and reflex response to gut distention in humans","volume":"108","author":"Iovino","year":"1995","journal-title":"Gastroenterol"},{"issue":"suppl","key":"10.1159\/000074972_bib40","doi-asserted-by":"crossref","first-page":"D71","DOI":"10.1046\/j.1440-1746.2000.02178.x","article-title":"Pathophysiological role of CCK in humans","volume":"15","author":"Otsuki","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1159\/000074972_bib41","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S1091-255X(99)80067-5","article-title":"Early increase in intestinal permeability in patients with severe acute pancreatitis: Correlation with endotoxemia, organ failure and mortality","volume":"3","author":"Ammori","year":"1999","journal-title":"J Gas-trointest Surg"},{"key":"10.1159\/000074972_bib42","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/bjs.1800830712","article-title":"Increased monocyte cytokine production in association with systemic complications in acute pancreatitis","volume":"83","author":"McKay","year":"1996","journal-title":"Br J Surg"},{"key":"10.1159\/000074972_bib43","first-page":"236","article-title":"Inervaci\u00f3in macrosc\u00f3ipica duodeno-pancre\u00e1itica en la rata: Clave de los cambios secretorios del \u2018pancreoin\u2019 induci-dos por la solarectom\u00eda, vaguectom\u00eda y doble duodenotom\u00eda peri-Vateriana","volume":"20","author":"Tiscornia","year":"1990","journal-title":"Ac Ge La"},{"key":"10.1159\/000074972_bib44","first-page":"157","article-title":"Biliary acute pancreatitis review","volume":"6","author":"Tiscornia","year":"2000","journal-title":"World J Gastroenterol"},{"key":"10.1159\/000074972_bib45","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0165-6147(90)90233-X","article-title":"Neurogenic inflammation: Interaction between mast cells and nerves","volume":"11","author":"Kiernan","year":"1990","journal-title":"Trends Pharmacol Sci"},{"key":"10.1159\/000074972_bib46","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1001\/archsurg.1997.01430350081013","article-title":"Pancreatic ascites as a powerful inducer of inflammatory cytokines: Role of known versus unknown factors","volume":"132","author":"Denham","year":"1997","journal-title":"Arch Surg"},{"issue":"suppl 1","key":"10.1159\/000074972_bib47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000051455","article-title":"New approaches to acute pancreatitis: Role of inflammatory mediators","volume":"60","author":"Norman","year":"1999","journal-title":"Digestion"},{"key":"10.1159\/000074972_bib48","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0002-9610(97)00240-7","article-title":"The role of cytokines in the pathogenesis of acute pancreatitis","volume":"175","author":"Norman","year":"1998","journal-title":"Am J Surg"},{"key":"10.1159\/000074972_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00006676-199501000-00001","article-title":"Neurohormonal control of human pancreatic exocrine secretion","volume":"10","author":"Adler","year":"1995","journal-title":"Pancreas"},{"key":"10.1159\/000074972_bib50","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/0016-5085(95)90439-5","article-title":"The sympathetic nervous system modulates perception and reflex response to gut distention in humans","volume":"108","author":"Iovino","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1159\/000074972_bib51","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3109\/00365528909089256","article-title":"Topical treatment of ulcerative proctitis with lidocaine","volume":"24","author":"Bj\u00f6rk","year":"1989","journal-title":"Scand J Gastroenterol"},{"key":"10.1159\/000074972_bib52","first-page":"G560","article-title":"Beneficial effects of local or systemic lidocaine in experimental colitis","volume":"266","author":"McCafferty","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1159\/000074972_bib53","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1748-1716.1983.tb07197.x","article-title":"The involvement of intramural nerves in cholera toxin induced intestinal secretion","volume":"117","author":"Cassuto","year":"1983","journal-title":"Acta Physiol Scand"},{"key":"10.1159\/000074972_bib54","first-page":"215","article-title":"An analysis of the mechanism of action of local anaesthetic inhibition of platelet aggregation and secretion","volume":"197","author":"Feinstein","year":"1976","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1159\/000074972_bib55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1182\/blood.V56.2.203.203","article-title":"Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites","volume":"56","author":"Mac Gregor","year":"1980","journal-title":"Blood"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390303800716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390303800716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T18:08:27Z","timestamp":1704996507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390303800716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S1424390303800716"],"URL":"https:\/\/doi.org\/10.1159\/000074972","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}