{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:11:34Z","timestamp":1745554294508,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background: &lt;\/i&gt;Blood coagulation factor XIII (F-XIII) promotes cross-linking of fibrin during blood coagulation. Impaired clot stabilization in patients with genetic deficiencies of F-XIII is associated with marked pathologies of wound healing. &lt;i&gt;Methods:&lt;\/i&gt; 60 rats given carbon tetrachloride underwent ileal anastomosis after which they received albumin (Alb animals) or F-XIII concentrate (F-XIII animals) immediately after surgery and daily thereafter until day 2 or 4 and were euthanized on day 3 or 5, respectively, or until day 5 and were euthanized on day 7, 10, or 21. We measured the plasma F-XIII activity and anastomotic tensile strength, followed by immunohistochemical localization of F-XIII subunit A within anastomoses.&lt;i&gt; Results:&lt;\/i&gt; On day 3, there were no significant differences between Alb and F-XIII animals for plasma F-XIII activity and tensile strength, and both groups of animals showed little immunostaining for F-XIII on anastomoses. Plasma F-XIII activities did not differ between Alb and F-XIII animals on day 5 (115.8 \u00b1 16.8 vs. 137.3 \u00b1 14.9%). Although the tensile strength in both groups was increased compared with that of day 3, that in F-XIII animals (129.8 \u00b1 3.3 gf) was significantly higher than that in Alb animals (100.8 \u00b1 5.3 gf, p = 0.014). F-XIII animals showed de novo collagen fibers and intense immunoreactivity of F-XIII in the extracellular matrix around the anastomoses. Similar differences occurred on day 7 but not days 10 and 21. &lt;i&gt;Conclusions: &lt;\/i&gt;F-XIII concentrate may accelerate the early healing process of intestinal anastomosis because of the protein\u2019s accumulation in situ.<\/jats:p>","DOI":"10.1159\/000075075","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T08:52:58Z","timestamp":1074675178000},"page":"53-58","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of Coagulation Factor XIII Concentrate for Reversing Loss of Tensile Strength of Rat Intestinal Anastomoses"],"prefix":"10.1159","volume":"36","author":[{"given":"H.","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Endoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Tani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(99)00023-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000051893"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0020.1999.284280413.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03322-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(83)90144-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1999.5765"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6164"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005541512152"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.5985"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2002.6495"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:59:08Z","timestamp":1745467148000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000075075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000075075","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"type":"print","value":"0014-312X"},{"type":"electronic","value":"1421-9921"}],"subject":[],"published":{"date-parts":[[2004]]}}}