{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:07:28Z","timestamp":1767650848071,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Background:<\/i> Allergic disorders are characterized by a systemic involvement of the immune response. There is a clear link between allergic rhinitis and asthma. Bronchial hyperreactivity (BHR) may be present in rhinitics. Smaller airways may also be impaired in mild asthma. This study aimed at evaluating a group of subjects suffering from perennial allergic rhinitis alone to investigate the presence of BHR and spirometric impairment. <i>Methods:<\/i> One hundred rhinitics sensitized only to perennial allergens were evaluated. Spirometry and methacholine bronchial challenge were performed. <i>Results:<\/i> Five rhinitics showed reduced values of forced expiratory volume\/1 s (FEV<sub>1<\/sub>) without symptoms of asthma. Forty-eight rhinitics had reduced forced expiratory flow at 25 and 75% of pulmonary volume (FEF<sub>25\u201375<\/sub>) values. Seventy-two patients showed a positive methacholine challenge. In this group, reduced values of FVC (p < 0.05), FEV<sub>1<\/sub> (p < 0.05), and FEF<sub>25\u201375<\/sub> (p < 0.01) were demonstrated in comparison with BHR-negative rhinitics. There was a relationship between the degree of BHR and FEV<sub>1<\/sub> values (p < 0.05) and FEF<sub>25\u201375<\/sub> values (p < 0.01). <i>Conclusions:<\/i> This study evidences that an impairment of spirometric parameters may be observed in patients with perennial allergic rhinitis alone. A high percentage of these patients have BHR. Thus, new management strategies should be employed in rhinitics.<\/jats:p>","DOI":"10.1159\/000075249","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T09:25:47Z","timestamp":1071825947000},"page":"14-18","source":"Crossref","is-referenced-by-count":33,"title":["Bronchial Hyperreactivity and Spirometric Impairment in Patients with Perennial Allergic Rhinitis"],"prefix":"10.1159","volume":"133","author":[{"given":"Giorgio","family":"Ciprandi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Angela","family":"Tosca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Vizzaccaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-9725.2003.00062.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1148"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-9725.2003.00054.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00277802"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-9725.2003.00055.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.121701"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01315.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2000.0814"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.1o3264.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:00:47Z","timestamp":1745467247000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000075249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000075249","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2004]]}}}