{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:25:24Z","timestamp":1791325524504,"version":"4.3.1"},"reference-count":6,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Previous studies suggest that allergen-specific immunotherapy (SIT) with a single allergen may prevent sensitization to other airborne allergens. &lt;i&gt;Objective:&lt;\/i&gt; To assess the effectiveness of injection SIT in preventing sensitization to birch and ragweed pollen north of Milan, a geographical area that was recently colonized by these two airborne allergens. &lt;i&gt;Methods:&lt;\/i&gt; 691 adult patients monosensitized to grass (n = 342), pellitory (n = 76), ragweed (n = 66), birch (n = 112), and house dust mite (n = 95) were studied. 284 (41%) of them received injection SIT as part of routine outpatient care; the remaining 407 (59%) not submitted to SIT, served as controls. All patients underwent follow-up visits after no less than 2 years in order to detect possible new sensitization to birch and\/or ragweed. &lt;i&gt;Results:&lt;\/i&gt; 227 (33%) patients became sensitized to birch and\/or ragweed pollen during the follow-up period. Surprisingly, the prevalence of new sensitizations was significantly higher among subjects receiving SIT (132\/284; 46%) than among those not receiving SIT (95\/407; 23%; p &lt; 0.001). 27 subjects developed new sensitization to birch and\/or ragweed pollen while undergoing SIT. These findings were consistent in all subgroups with different airborne allergies. &lt;i&gt;Conclusion:&lt;\/i&gt; In this study, injection SIT did not exert any preventive effect against denovo&lt;i&gt;&lt;\/i&gt;sensitization to the two novel airborne allergens, birch and ragweed pollen, in adult monosensitized patients.<\/jats:p>","DOI":"10.1159\/000075253","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T09:25:47Z","timestamp":1071825947000},"page":"49-54","source":"Crossref","is-referenced-by-count":10,"title":["Injection Immunotherapy with Different Airborne Allergens Did Not Prevent de novo Sensitization to Ragweed and Birch Pollen North of Milan"],"prefix":"10.1159","volume":"133","author":[{"given":"Riccardo","family":"Asero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410702"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.23766.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00120.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2123"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000053704"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.13248.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:00:51Z","timestamp":1745467251000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000075253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000075253","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}