{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:18:26Z","timestamp":1758637106864,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To test the hypothesis that the nervous system participates in modulating the immune response during experimental African trypanosomiasis caused by &lt;i&gt;Trypanosoma brucei brucei&lt;\/i&gt;. &lt;i&gt;Methods and Results:&lt;\/i&gt; Using in situ hybridization and immunochemistry, we studied the effects of splenic sympathectomy on mRNA gene expression and protein production of IL-1\u03b2 and IL-6 in splenic and peritoneal macrophages (PM\u03a6) of Sprague-Dawley rats infected with &lt;i&gt;T. brucei brucei&lt;\/i&gt; and non-infected rats. The enhancements of mRNA gene expression and production of IL-1\u03b2 and IL-6 by peritoneal macrophages were significantly suppressed by the splenic sympathectomy in both infected and non-infected rats. &lt;i&gt;Conclusions:&lt;\/i&gt; Our data indicate a probably stimulatory role of the sympathetic nervous system during the host immune response in both normal and &lt;i&gt;T. brucei brucei&lt;\/i&gt;-infected rats.<\/jats:p>","DOI":"10.1159\/000075320","type":"journal-article","created":{"date-parts":[[2004,2,6]],"date-time":"2004-02-06T10:57:01Z","timestamp":1076065021000},"page":"113-118","source":"Crossref","is-referenced-by-count":3,"title":["Splenic Denervation Suppresses mRNA Gene Expression and Protein Production of IL-1\u03b2 and IL-6 by Peritoneal Macrophages in both &lt;i&gt;Trypanosoma brucei brucei&lt;\/i&gt;-Infected and Non-Infected Rats"],"prefix":"10.1159","volume":"11","author":[{"given":"Yajuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhilun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Svar\u00e9n-Quiding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volkan","family":"\u00d6zenci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moiz","family":"Bakhiet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000026363"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1403.2000.00031.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1999.00364.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(95)00073-B"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(96)00126-9"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:01:47Z","timestamp":1745467307000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000075320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000075320","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"type":"print","value":"1021-7401"},{"type":"electronic","value":"1423-0216"}],"subject":[],"published":{"date-parts":[[2004]]}}}