{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:54:21Z","timestamp":1761400461451,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Objective: &lt;\/i&gt;To evaluate the possible biological aspects of \u2018unexplained physical symptoms\u2019, this study examined serotonergic and noradrenergic monoamino acids in somatoform disorders and\/or depression. &lt;i&gt;Methods:&lt;\/i&gt; Blood samples of 150 subjects from 4 groups (somatization syndrome; depression; depression and somatization; controls) were analyzed for amino acids contributing to the serotonergic and noradrenergic system and peripheral muscle energy balance (tryptophan, valine, leucine, isoleucine, phenylalanine and tyrosine). &lt;i&gt;Results:&lt;\/i&gt; Tryptophan, branched chain amino acids and other serotonergic amino acids were decreased in patients with somatoform symptoms, even when no depression was present. &lt;i&gt;Conclusions:&lt;\/i&gt; We conclude that serotonergic amino acids are biological correlates of multiple unexplained symptoms. Ways of action do not only involve brain mechanisms, but also energy metabolism in peripheral muscles.<\/jats:p>","DOI":"10.1159\/000075335","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T08:52:58Z","timestamp":1074675178000},"page":"24-29","source":"Crossref","is-referenced-by-count":39,"title":["Psychobiological Aspects of Somatoform Disorders: Contributions of Monoaminergic Transmitter Systems"],"prefix":"10.1159","volume":"49","author":[{"given":"Winfried","family":"Rief","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Pilger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ihle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Verkerk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Scharpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Maes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00204-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199611000-00005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07044-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701003580"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-9961(03)00030-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(97)00002-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(01)00338-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(00)00042-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00025-1"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75335","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:02:03Z","timestamp":1745467323000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000075335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000075335","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"type":"print","value":"0302-282X"},{"type":"electronic","value":"1423-0224"}],"subject":[],"published":{"date-parts":[[2004]]}}}