{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:45:51Z","timestamp":1773081951411,"version":"3.50.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>This study investigated response rate, toxicity, and influence on intra- and postoperative complications of neoadjuvant concurrent chemoradiation in locally advanced (Figo IB2\u2013IIIB) cervical carcinomas. Twenty-eight patients (median age 46.5 years, age range 29\u201373 years), diagnosed as having squamous cell carcinomas (n = 21), adenocarcinomas (n = 6), and undifferentiated carcinoma (n = 1), entered this study. The chemoradiation protocol included external radiotherapy to the pelvis (39.6 Gy), intra-arterial or intravenous infusion of cisplatin (70\u00a0mg\/m&lt;sup&gt;2&lt;\/sup&gt; on days 1 and 22), and 24-hour continuous intravenous infusion of 5-fluorouracil (700 mg\/m&lt;sup&gt;2&lt;\/sup&gt; on days 1\u20134 and 22\u201325). Two weeks after the end of chemoradiotherapy, the patients underwent restaging followed by suitable operation including pelvic lymphadenectomy. The median follow-up period in the surviving patients was 13.1 months. The response rate for chemoradiation was 93% (26\/28). The 2-year disease free survival was 85.2%. Grade 3\u20134 neutropenia was observed in 14 patients (50%), 4 patients (14%) showed grade 3 anemia, and 5 patients (17.8%) showed grade 3\u20134 thrombocytopenia. Nineteen patients (67.8%) could undergo surgery after concurrent chemoradiation. Pathological examination revealed a complete response (pT0) in 7 patients, and 5 patients showed only microscopic residual disease (pTmic). In 4 patients, there were intraoperative complications: vesical lesions in 2 (10%) and small intestine lesions in 2 (10%). Neoadjuvant therapy with concurrent chemoradiation for locally advanced cervical carcinoma is effective, safe, and useful for increasing operability rates as well as decreasing intra- and postoperative complications. Therefore, neoadjuvant concurrent chemoradiation should be considered for treatment in patients with locally advanced cervical carcinomas who could not undergo primary operation.<\/jats:p>","DOI":"10.1159\/000075385","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T09:25:47Z","timestamp":1071825947000},"page":"93-99","source":"Crossref","is-referenced-by-count":8,"title":["Usefulness of Preoperative Chemoradiation in Locally Advanced Cervical Carcinoma"],"prefix":"10.1159","volume":"57","author":[{"given":"Kiyosumi","family":"Shibata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitaka","family":"Kikkawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Terauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kajiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiko","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00145-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.4960"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401501"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401503"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904153401502"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1168"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5862"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf196"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6195"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00482-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.1.179"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:02:51Z","timestamp":1745467371000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000075385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000075385","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}