{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:11:45Z","timestamp":1745554305991,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; To determine the secretion of corticosterone (CCS) both in vivo and in vitro during different intervals after orchidectomy in male rats. &lt;i&gt;Methods:&lt;\/i&gt; Three- and 12-month-old rats had been orchidectomized 0, 3, 6, or 9 months before decapitation. &lt;i&gt;Results:&lt;\/i&gt; Orchidectomy increased the concentrations of plasma CCS, the basal release of CCS, and the adenosine 3\u2032, 5\u2032-cyclic monophosphate (cAMP) production in rat zona fasciculata reticularis (ZFR) cells. The forskolin\/3-isobutyl-&lt;i&gt;l&lt;\/i&gt;-methylxanthine-stimulated releases of CCS and cAMP production by ZFR cells were higher in rats with chronic hypogonadism. The CCS release from ZFR cells of orchidectomized rat was not altered by 8-bromo-cAMP treatment. Orchidectomy enhanced the stimulatory effect of deoxycorticosterone on CCS release in ZFR cells. &lt;i&gt;Conclusion:&lt;\/i&gt; These results suggest that orchidectomy-related increases of CCS secretion in rats are associated with an increase of adenylate cyclase activity, cAMP generation, and 11-\u03b2-hydroxylase activity in ZFR cells.<\/jats:p>","DOI":"10.1159\/000075386","type":"journal-article","created":{"date-parts":[[2003,12,5]],"date-time":"2003-12-05T08:39:23Z","timestamp":1070613563000},"page":"84-91","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Chronic Hypogonadism on Corticosterone Secretion and Cyclic AMP Production in Male Rat Adrenocortical Cells"],"prefix":"10.1159","volume":"61","author":[{"given":"Ming-Jae","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Mei","family":"Kau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulus S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1994.1043"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(94)90018-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.59.329"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.5.2430"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(98)00063-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(03)00045-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)02015-B"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00413-9"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75386","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:02:52Z","timestamp":1745467372000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000075386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000075386","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2004]]}}}