{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:35:01Z","timestamp":1787506501952,"version":"build-2736575974"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Aims:<\/i> To study the relationships between serum IGF-1, IGFBP-3 and IGFBP-2 and interleukin (IL)-1\u03b2 and IL-6 in inflammatory bowel disease (IBD). <i>Methods:<\/i> Thirty-seven patients (18 males, 19 females, aged 8.8\u201326.1 years) with IBD (Crohn\u2019s disease, CD, n = 17, and ulcerative colitis, UC, n = 20) were studied. Patients were in relapse or remission according to established criteria. Serum IGF-1, IGFBP-3, IGFBP-2, IL-1\u03b2 and IL-6 levels were determined in patients and 15 healthy controls (aged 8.2\u201319.0 years). <i>Results:<\/i> IGF-1 levels were lower in patients with CD in relapse compared with controls (p < 0.05). IGFBP-2 levels were higher in CD in relapse compared with other groups (all p < 0.05). In CD and UC patients (n = 37), IGF-1 levels were inversely correlated with the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). IGFBP-2 levels correlated positively with ESR and IL-1\u03b2. IL-6 levels correlated positively with ESR and CRP. IL-1\u03b2 levels were elevated in CD in relapse compared to controls (p < 0.05) and were higher in UC in relapse than in other groups (all p < 0.05). In combined CD\/UC patients in relapse (n = 20), IL-1\u03b2 levels were higher (p < 0.05) in patients with recto-sigmoiditis (n = 5) than in other patients. <i>Conclusions:<\/i> IGF-1, IGFBP-2 levels were related to IL levels, disease activity and anatomical distribution, consistent with active inflammation modifying the IGF-IGFBP system, possibly relevant to disturbance of growth.<\/jats:p>","DOI":"10.1159\/000075699","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T02:34:55Z","timestamp":1071801295000},"page":"159-164","source":"Crossref","is-referenced-by-count":52,"title":["Relationships between Serum IGF-1, IGFBP-2, Interleukin-1Beta and Interleukin-6 in Inflammatory Bowel Disease"],"prefix":"10.1159","volume":"61","author":[{"given":"Maria E.","family":"Street","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GianLuigi","family":"de\u2019Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Camacho-H\u00fcbner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Giovannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angela","family":"Ziveri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Bacchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Bernasconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Sansebastiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin O.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00562.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/en.135.4.1367"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.1.122"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03339-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199802)174:2<240::AID-JCP11>3.3.CO;2-W"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2235(95)00035-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1054\/ghir.2001.0233"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050285"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1054\/ghir.2001.0248"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.694"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.9.2684"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.3.938"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.12.5488"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.11.4818"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:05:24Z","timestamp":1745453124000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000075699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000075699","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}