{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:07:48Z","timestamp":1770822468006,"version":"3.50.1"},"reference-count":7,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T00:00:00Z","timestamp":1072137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T00:00:00Z","timestamp":1072137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Idiopathic cerebral vein thrombosis (iCVT) represents approximately 30% of the cases of cerebral vein thrombosis (CVT). New, inherited \u2013 factor V Leiden (FVL) and prothrombin gene mutation (PTHRA&lt;sup&gt;20210&lt;\/sup&gt;) \u2013 and inherited\/acquired \u2013 hyperhomocysteinemia (HHcy) \u2013 prothrombotic conditions have been detected recently. &lt;i&gt;Methods:&lt;\/i&gt; We assessed fasting plasma homocysteine (Hcy) levels and main Hcy determinants, FVL and PTHRA&lt;sup&gt;20210&lt;\/sup&gt; in 30 patients with documented iCVT and 40 age- and sex-matched healthy subjects. &lt;i&gt;Results:&lt;\/i&gt; A strong and significant association of PTHRA&lt;sup&gt;20210&lt;\/sup&gt; [30% (9\/30) vs. 2.5% (1\/40) iCVT vs. controls, respectively, p = 0.001; OR = 16.174, p = 0.002] and HHcy [13\/30 (43.3%) vs. 4\/40 (10%) iCVT vs. controls, respectively; p = 0.002, OR = 6.88, p = 0.002] with iCVT was found. &lt;i&gt;Conclusions:&lt;\/i&gt; PTHRA&lt;sup&gt;20210&lt;\/sup&gt; and HHcy should be considered when screening for thrombophilia and should be assessed in patients with a family or personal history of CVT.<\/jats:p>","DOI":"10.1159\/000075784","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T08:52:58Z","timestamp":1074675178000},"page":"153-159","source":"Crossref","is-referenced-by-count":47,"title":["Hyperhomocysteinemia and Other Newly Recognized Inherited Coagulation Disorders (Factor V Leiden and Prothrombin Gene Mutation) in Patients with Idiopathic Cerebral Vein Thrombosis"],"prefix":"10.1159","volume":"17","author":[{"given":"Paolo","family":"Ventura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Cobelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Marietta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Panini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Salvioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(92)90030-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07468-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01028.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806183382502"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603213341203"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-111"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/75784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:06:34Z","timestamp":1745467594000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000075784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,23]]},"references-count":7,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000075784","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,23]]}}}