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Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; The role of COX-2 for renal function during renal development, for physiology and pathophysiology of renal diseases and the side effects of available COX-2 inhibitors, has gained increasing interest. We aimed therefore to review the respective role of renal COX-2. &lt;i&gt;Methods:&lt;\/i&gt; Review of relevant recent publications in the field, and in addition of in part unpublished data obtained in our laboratories. &lt;i&gt;Results:&lt;\/i&gt; COX-2 is \u2018constitutively\u2019 localized in the kidney i.e. in macula densa, TALH, interstitial cells, and is of utmost importance for normal renal development. Renal COX-2 is regulated by for example sodium and volume intake, angiotensin II, glucocorticoids often involving specific COX-2 promotor response elements. COX-2 derived prostanoids are required for preservation of renal blood flow and glomerular filtration especially in states of fluid deficit, they promote natriuresis, and furthermore may stimulate renin secretion during low-sodium intake\/loop diuretic use. Conversely, COX-2 inhibitors decrease glomerular filtration, and renal perfusion, sometimes even causing acute renal failure. In addition, COX-2 inhibitors cause sodium retention, edema formation, cardiac failure and hypertension. The role of COX-2 derived prostanoids in renal inflammation or failure including diabetic nephropathy and renal transplantation remains at present controversial. &lt;i&gt;Conclusion:&lt;\/i&gt; COX-2 is one of the major players in renal physiology and pathophysiology. One focus of future work should be placed on COX-2 in primary renal diseases.<\/jats:p>","DOI":"10.1159\/000075811","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T14:16:23Z","timestamp":1100873783000},"page":"43-62","source":"Crossref","is-referenced-by-count":35,"title":["Renal Cyclooxygenase-2 (Cox-2)"],"prefix":"10.1159","volume":"27","author":[{"given":"Bernhard K.","family":"Kr\u00e4mer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin 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