{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:35:55Z","timestamp":1774942555984,"version":"3.50.1"},"reference-count":5,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; Collagen cross-linking using combined riboflavin\/UVA treatment has been shown to increase the biomechanical rigidity of the cornea and has been used successfully for the treatment of progressive keratoconus. From morphological and biochemical investigations, a different degree of cross-linking for the anterior and posterior stroma by the treatment is suggested. The present study was undertaken to better evaluate this effect by testing the thermomechanical behavior. &lt;i&gt;Methods:&lt;\/i&gt; Ten 10 \u00d7 5 mm corneal strips from porcine cadaver eyes enucleated within 5 h post mortem were cross-linked using the photosensitizer riboflavin and UVA irradiation (370 nm, irradiance = 3 mW\/cm&lt;sup&gt;2&lt;\/sup&gt;) for 30 min and compared to ten untreated corneal strips and ten corneal strips cross-linked with 0.1% glutaraldehyde. The temperature in a water bath was raised from 60 to 95\u00b0C with temperature increments of 1\u00b0C per minute. The hydrothermal shrinkage of the corneal strips was measured in 2.5\u00b0C steps using a micrometer. In addition, six 10-mm whole corneal buttons were cross-linked with riboflavin\/UVA and immersed into water at 70 or 75\u00b0C. &lt;i&gt;Results:&lt;\/i&gt; The maximal hydrothermal shrinkage for the untreated control specimens and the posterior portion of the riboflavin\/UVA-treated corneas was at 70\u00b0C, for the anterior portion of the cornea cross-linked by riboflavin\/UVA at 75\u00b0C and for glutaraldehyde-cross-linked cornea at 90\u00b0C. In the cross-linked corneal buttons, a typical mushroom-like shape was observed at 70\u00b0C and a cylinder shape at 75\u00b0C. &lt;i&gt;Conclusions:&lt;\/i&gt; The different degree of collagen cross-linking in the corneal stroma after riboflavin\/UVA treatment is reflected by the differences in the maximal shrinkage temperature of the anterior and posterior portion. Therefore, in the corneas cross-linked with riboflavin\/UVA a higher shrinkage temperature was observed for the anterior portion of the cornea (75\u00b0C) compared to the posterior stroma (70\u00b0C) due to the higher degree of cross-linking of the anterior stroma. The anterior localization of the cross-linking effect is advantageous for the endothelium and for the preservation of the anterior corneal curvature.<\/jats:p>","DOI":"10.1159\/000076150","type":"journal-article","created":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T16:06:30Z","timestamp":1078243590000},"page":"136-140","source":"Crossref","is-referenced-by-count":113,"title":["Thermomechanical Behavior of Collagen-Cross-Linked Porcine Cornea"],"prefix":"10.1159","volume":"218","author":[{"given":"Eberhard","family":"Spoerl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Wollensak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dag-Daniel","family":"Dittert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Seiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(03)00407-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.4.437"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00412-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(00)00310-2"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:09:23Z","timestamp":1745467763000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000076150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000076150","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}