{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:43:06Z","timestamp":1759963386493,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>The Fas antigen is a cell surface receptor-mediating cell apoptosis. Recent studies have demonstrated that Fas-associated apoptosis is involved in the pathogenesis of Alzheimer\u2019s disease (AD). Moreover, the Fas gene is located on chromosome 10q24.1, a region of linkage to late-onset AD (LOAD). These two criteria, pathobiological and positional, make the Fas antigen an interesting candidate for an association with AD. We performed a case-control association study between the common A\/G polymorphism at position \u2013670 in the Fas gene (TNFSRF6) promoter and sporadic AD in Jews, investigating whether this locus acts as a risk factor or whether it has a modifying effect. An association has recently been detected by Feuk et al. in the Scottish population between this locus and the risk of early-onset AD (EOAD), but not of LOAD. In agreement with Feuk et al., we found no association between this locus and the risk of LOAD (n = 86). However, in our small sample of patients with EOAD (n = 19), no association was found either. No interactive effect was found between the Fas promoter polymorphism at position \u2013670 and the known risk factor of LOAD, apolipoprotein E &amp;#917;4, and no association was detected with disease progression. These findings show no evidence for an association between the Fas promoter polymorphism at position \u2013670 and AD in our population.<\/jats:p>","DOI":"10.1159\/000076347","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T08:52:58Z","timestamp":1074675178000},"page":"143-146","source":"Crossref","is-referenced-by-count":8,"title":["The Fas Promoter Polymorphism at Position \u2013670 Is Not Associated with Late-Onset Sporadic Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"17","author":[{"given":"Hanna","family":"Rosenmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeev","family":"Meiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Kahana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoja","family":"Aladjem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Ben-Yehuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Grenader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Wertman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oded","family":"Abramsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1086\/302710"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00476-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1995.1025"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00699-Q"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2302"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2304"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s004390000383"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(97)00081-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0614-1"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:10:35Z","timestamp":1745467835000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000076347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000076347","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2004]]}}}