{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:37:18Z","timestamp":1771069038108,"version":"3.50.1"},"reference-count":6,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>Neprilysin (NEP), also known as neutral endopeptidase, enkephalinase, CD 10, and common acute lymphoblastic leukemia antigen, is a 97-kD protein. NEP can degrade amyloid \u03b2 peptides, and its mRNA and protein levels are known to be reduced in the brains of patients with Alzheimer\u2019s disease (AD), making the &lt;i&gt;NEP&lt;\/i&gt; gene a substantial candidate for an AD risk factor. We examined the genetic association of three &lt;i&gt;NEP&lt;\/i&gt; polymorphisms, a GT-repeat polymorphism and two single nucleotide polymorphisms (SNPs, \u20131075A&gt;G and \u20131284G&gt;C) in its promoter region, with AD in a Japanese case-control sample (240 patients and 163 controls). The GT-repeat polymorphism, but not the SNPs, was significantly associated with late-onset AD (p = 0.0007). Our findings suggest that the GT-repeat polymorphism in the promoter region of the &lt;i&gt;NEP&lt;\/i&gt; gene or some other unknown polymorphisms, which are in a linkage disequilibrium, confer a susceptibility to late-onset AD.<\/jats:p>","DOI":"10.1159\/000076351","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T08:52:58Z","timestamp":1074675178000},"page":"164-169","source":"Crossref","is-referenced-by-count":32,"title":["Association of the &lt;i&gt;Neprilysin&lt;\/i&gt; Gene with Susceptibility to Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"17","author":[{"given":"Ayumu","family":"Sakai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ujike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Nakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Takehisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaki","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Kanzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutoshi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikatsu","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetoshi","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5440.735"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/72237"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059946"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008511200"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01675-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.6.817"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:10:39Z","timestamp":1745467839000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000076351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000076351","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}