{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:44:37Z","timestamp":1761057877467,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Background:<\/i> In patients showing multiple reactivity to seasonal airborne allergens, a skin prick test (SPT) with <i>Parietaria<\/i> pollen scores frequently negative, suggesting that profilin from <i>Parietaria<\/i> might not share IgE-binding epitopes with profilin from botanically unrelated airborne allergens. This study investigated the immunologic cross-reactivity between profilins from <i>Parietaria<\/i>, grass and birch pollen. <i>Methods:<\/i> 36 patients hypersensitive to birch profilin, Bet v 2, underwent SPT with <i>Parietaria<\/i>, and IgE to both whole <i>Parietaria<\/i> pollen and <i>Phleum<\/i> profilin were sought in their sera by ELISA. In ELISA inhibition studies, IgE reactivity to <i>Phleum<\/i> profilin was measured before and after absorption of sera from <i>Parietaria<\/i> reactors with both whole <i>Parietaria<\/i> pollen extract, and Par j 1\/Par j 2 fraction. Further, their IgE reactivity to whole <i>Parietaria<\/i> pollen was measured before and after absorption with the Par j 1\/Par j 2 fraction. <i>Results:<\/i> All sera showed IgE reactivity to <i>Phleum<\/i> profilin. Only 14\/36 (39%) patients had a positive SPT to <i>Parietaria<\/i> and 17\/36 (47%) showed IgE to <i>Parietaria<\/i>. Absorption of sera from <i>Parietaria<\/i> reactors with whole <i>Parietaria <\/i>extract caused a marked reduction in IgE reactivity to grass profilin; in contrast, absorption of sera with the Par j 1\/Par j 2 fraction did not exert any inhibitory effect on IgE reactivity to grass profilin. Absorption of sera with the Par j 1\/Par j 2 fraction markedly reduced IgE reactivity to whole <i>Parietaria<\/i> extract in 8\/9 cases. <i>Conclusion:<\/i> Less than 50% of patients sensitized to birch and grass profilin cross-react to <i>Parietaria<\/i> profilin. In most cases, cross-reactors are hypersensitive to major, specific <i>Parietaria<\/i> allergens as well. This findings may be of practical relevance when the prescription of specific immunotherapy is considered.<\/jats:p>","DOI":"10.1159\/000076384","type":"journal-article","created":{"date-parts":[[2004,1,30]],"date-time":"2004-01-30T09:31:09Z","timestamp":1075455069000},"page":"121-124","source":"Crossref","is-referenced-by-count":20,"title":["<i>Parietaria<\/i> Profilin Shows Only Limited Cross-Reactivity with Birch and Grass Profilins"],"prefix":"10.1159","volume":"133","author":[{"given":"Riccardo","family":"Asero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Mistrello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Roncarolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Amato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.2.377"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1976.9999"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1611"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126380"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000053797"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1376"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:11:09Z","timestamp":1745467869000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000076384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000076384","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2004]]}}}