{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:12:33Z","timestamp":1745554353971,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; For evaluating the characteristics of human neoplasms, investigation of regulators of cell cycle progression is important. We studied three components of the Cip\/Kip family, p57, p27 and p21, in malignant lymphomas of the thyroid. &lt;i&gt;Methods:&lt;\/i&gt; We immunohistochemically investigated the expression of the three proteins for 49 cases of thyroid lymphomas, as well as 10 cases of chronic thyroiditis. &lt;i&gt;Results:&lt;\/i&gt; In infiltrating lymphocytes in chronic thyroiditis, p57 and p27 were diffusely expressed, whereas p21 immunoreactivity was only occasionally observed. In lymphoma, decreased expression of p57 (less than 50% of lymphoma cells were positive) was observed in 24 cases (49.0%). p57 expression was inversely linked to the MIB-1 labeling index, grade of malignancy and aberrant p53 expression. Decreased expression of p27 was observed in 25 cases (51.0%), which was also related to the MIB-1 labeling index and aberrant p53 expression. On the other hand, p21 expression was occasional, and when the cut-off value was set at 3%, 38 cases (77.6%) were regarded as negative. P21 expression was not linked to any clinicopathological parameters. &lt;i&gt;Conclusion:&lt;\/i&gt; These findings suggest that, among the 3 components of the Cip\/Kip family, p57 and p27 play a role in negatively regulating the cell proliferation of thyroid lymphoma cells and decreased expression of them contributes to the progression of this disease.<\/jats:p>","DOI":"10.1159\/000076472","type":"journal-article","created":{"date-parts":[[2004,4,2]],"date-time":"2004-04-02T06:46:29Z","timestamp":1080888389000},"page":"164-170","source":"Crossref","is-referenced-by-count":7,"title":["Expression of the Components of the Cip\/Kip Family in Malignant Lymphoma of the Thyroid"],"prefix":"10.1159","volume":"71","author":[{"given":"Yasuhiro","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Matsuzuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariaki","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Nakamine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennichi","family":"Kakudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Kuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900434"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200005000-00001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/366701a0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.124929"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1435"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880444"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200110000-00004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000055378"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01283.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00352-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10338.abs"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00319-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jso.10172"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11079"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300114"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.09.147"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00624-3"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:11:52Z","timestamp":1745467912000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000076472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000076472","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"type":"print","value":"1015-2008"},{"type":"electronic","value":"1423-0291"}],"subject":[],"published":{"date-parts":[[2004]]}}}