{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T17:46:39Z","timestamp":1759513599392,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Nicotine was effective in the treatment of skin disorders attributable to neutrophils such as pyoderma gangrenosum and orogenital ulcerations due to Beh\u00e7et\u2019s disease. &lt;i&gt;Objective:&lt;\/i&gt; We assessed the efficacy of nicotine for treating skin disorders with prominent eosinophilic infiltration. &lt;i&gt;Patients and Methods:&lt;\/i&gt; A 67-year-old man with Kimura\u2019s disease was treated for 2 weeks with nicotine chewing gum (6 mg\/day). A 50-year-old woman with erythema nodosum with eosinophilic infiltration was treated for 4 weeks with transdermal nicotine patches (5 mg\/day). &lt;i&gt;Results:&lt;\/i&gt; Both patients showed a dramatic clinical and histopathological improvement. &lt;i&gt;Conclusion:&lt;\/i&gt; Our results suggest that nicotine may be useful for treating skin disorders with eosinophilic infiltration as well as neutrophilic dermatoses.<\/jats:p>","DOI":"10.1159\/000076492","type":"journal-article","created":{"date-parts":[[2004,4,2]],"date-time":"2004-04-02T06:46:29Z","timestamp":1080888389000},"page":"153-157","source":"Crossref","is-referenced-by-count":12,"title":["Skin Disorders with Prominent Eosinophilic Infiltration Treated Successfully with Nicotine"],"prefix":"10.1159","volume":"208","author":[{"given":"Takuro","family":"Kanekura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Usuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Kanzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,3,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012143432418"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.155.2.390"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12510590"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(99)00115-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02643.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:12:00Z","timestamp":1745467920000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000076492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000076492","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2004]]}}}