{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:45:30Z","timestamp":1761518730626,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Objective:<\/i> We tested the impact of commencement of GH replacement therapy in GH-deficient (GHD) adults on the circulating levels of other anterior pituitary and peripheral hormones and the need for re-evaluation of other hormone replacement therapies, especially the need for dose changes. <i>Methods:<\/i> 22 GHD patients were investigated in a double-blind randomized study and 90 GHD patients in an open study at baseline and after 6 and 12 months of GH replacement therapy. <i>Results: <\/i>In the placebo-controlled trial, the FT<sub>3<\/sub> levels increased after 6 months in the GH-treated group, and in the open study the FT<sub>3<\/sub> levels tended to increase. Other hormone concentrations did not change in either part of the study. Four patients required an increase in thyroxine dose, while 2 patients needed dose reduction. One originally euthyroid patient required thyroxine replacement. Two patients with originally conserved pituitary-adrenal function developed ACTH insufficiency. The hydrocortisone dose was increased in 1 and decreased in 1 of the 66 patients with secondary hypocortisolism. None of the females required any adjustment of sex hormone replacement therapy. Two of 37 males needed dose increase of testosterone, while 1 needed dose reduction. <i>Conclusion:<\/i> GH replacement therapy required dose adjustments regarding other hormone replacement therapies in 12.2% (n = 11), while initiation of new hormone replacement was performed in 3.3% (n = 3) of the 90 patients during the 1-year follow-up. Monitoring of pituitary hormone axes is advisable after commencement of GH replacement therapy, since changes of hormone replacement therapy was observed in a small but clinically significant number of patients.<\/jats:p>","DOI":"10.1159\/000076538","type":"journal-article","created":{"date-parts":[[2004,1,30]],"date-time":"2004-01-30T09:31:09Z","timestamp":1075455069000},"page":"211-217","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Growth Hormone Replacement Therapy on Pituitary Hormone Secretion and Hormone Replacement Therapies in GHD Adults"],"prefix":"10.1159","volume":"61","author":[{"given":"Erika","family":"Hubina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette","family":"Mersebach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5se Krogh","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Juul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Bjerregaard","family":"Sneppen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s I.","family":"G\u00f3th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.4.1416"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.11.4172"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000048126"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.11.3892"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530\/revreprod\/5.3.175"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000023186"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/en.135.6.2526"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.8.2886"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-4959(01)00315-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.379"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.3.744"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000053174"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.2.309"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.382"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.10.3493"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/0891693022305499"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1727"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:12:24Z","timestamp":1745467944000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000076538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2004,4,1]]},"published-print":{"date-parts":[[2004,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000076538","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2004]]}}}