{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:31:43Z","timestamp":1780943503570,"version":"3.54.1"},"reference-count":1,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The \u2018case-crossover\u2019 design is a strategy fitted to studying transient effects of intermittent exposure on acute-onset disease occurring shortly after exposure. It has the important advantage of eliminating most confounding variables, allowing a stronger causality inference. &lt;i&gt;Objectives:&lt;\/i&gt; The objective of the study was to evaluate the relationships between emergency room (ER) visits for asthma attacks and gaseous air pollution changes. &lt;i&gt;Methods:&lt;\/i&gt; The study included 549 individuals, 3\u201349 years old, visiting the ER during 1 year. Exposure to gaseous air pollutants (SO&lt;sub&gt;2&lt;\/sub&gt;, NO&lt;sub&gt;2&lt;\/sub&gt;, O&lt;sub&gt;3&lt;\/sub&gt;) on the same day and up to 4 days before was computed according to the patient\u2019s address. The statistical analysis included meteorological data as potential confounding variables. &lt;i&gt;Results:&lt;\/i&gt; No association could be shown between ER visits and SO&lt;sub&gt;2&lt;\/sub&gt; or NO&lt;sub&gt;2&lt;\/sub&gt; levels. In contrast, there was a statistically significant association between ER visits and mean O&lt;sub&gt;3&lt;\/sub&gt; levels, on the day of admission and also on D \u20132 and D \u20133. For an increase of 10 \u00b5g\/m&lt;sup&gt;3&lt;\/sup&gt;, the risk of requiring an ER admission increased by 6\u201310%. &lt;i&gt;Conclusions:&lt;\/i&gt; Using this new strategy, we confirmed that ozone changes lead to a moderate increase in risk of requiring an ER admission in asthmatic subjects.<\/jats:p>","DOI":"10.1159\/000076673","type":"journal-article","created":{"date-parts":[[2004,3,19]],"date-time":"2004-03-19T14:37:25Z","timestamp":1079707045000},"page":"134-137","source":"Crossref","is-referenced-by-count":33,"title":["Visits to the Emergency Room for Asthma Attacks and Short-Term Variations in Air Pollution"],"prefix":"10.1159","volume":"71","author":[{"given":"S.","family":"Boutin-Forzano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Adel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gratecos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Jullian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Garnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ramadour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lanteaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Lafay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Charpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00012.x"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:13:27Z","timestamp":1745468007000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000076673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":1,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000076673","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}