{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:35:24Z","timestamp":1770503724710,"version":"3.49.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; The aim of this study is to investigate the effects of resveratrol on histopathological changes, antioxidant status and lipid peroxidation, in torsion-detorsion injury in rat ovaries. &lt;i&gt;Method:&lt;\/i&gt; To determine whether ischemia followed by reperfusion can induce ovarian oxidative damage, we created a model of adnexal ischemia-reperfusion by using rats. Ischemia was induced by unilateral occlusion of the tubo-ovarian vessels for 3 h. Reperfusion was achieved by releasing the occlusion and restoring the circulation for 3 h. Thirty-two adult female albino rats were divided equally into 4 groups: sham operation, torsion, saline\/detorsion and resveratrol\/detorsion. Rats in the torsion group were killed after 360\u00b0 clockwise adnexal torsion for 3 h. Resveratrol was injected intraperitoneally 30 min before detorsion in the resveratrol\/detorsion group, and saline was administered in the saline\/detorsion group. After 3 h of adnexal detorsion in both of these groups, the rats were killed and adnexa were removed. The tissue levels of malondialdehyde, reduced glutathione and xanthine oxidase activity were measured. &lt;i&gt;Results:&lt;\/i&gt; Malondialdehyde and xanthine oxidase levels in the saline\/detorsion group were increased significantly when compared to the torsion and sham operation groups (p &lt; 0.001). Malondialdehyde levels in the resveratrol group were lower than in the saline\/detorsion group, and differences between the two groups were statistically significant (p &lt; 0.001). Xanthine oxidase levels in the resveratrol group were lower than in the saline\/detorsion and torsion groups, and differences between these groups were statistically significant (p &lt; 0.001). Reduced glutathione levels in the saline\/detorsion group were decreased significantly when compared to the torsion and sham operation groups. Reduced glutathione levels in the resveratrol group were significantly higher than in the saline\/detorsion group (p &lt; 0.006). Histological examination showed a significant improvement in ovarian morphology in the resveratrol-treated rats compared with the ischemia and ischemia-reperfusion groups. &lt;i&gt;Conclusion:&lt;\/i&gt; Our results demonstrated that intraperitoneal resveratrol administration reduced the lipid peroxidation products of ischemic rats and ovarian damage was reduced as indicated by histological examination.<\/jats:p>","DOI":"10.1159\/000076760","type":"journal-article","created":{"date-parts":[[2004,2,16]],"date-time":"2004-02-16T07:54:13Z","timestamp":1076918053000},"page":"218-223","source":"Crossref","is-referenced-by-count":29,"title":["Resveratrol, a Red Wine Constituent Polyphenol, Protects from Ischemia-Reperfusion Damage of the Ovaries"],"prefix":"10.1159","volume":"57","author":[{"given":"Seyma","family":"Hascalik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onder","family":"Celik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Turkoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Hascalik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u0131lmaz","family":"Cigremis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Mizrak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saim","family":"Yologlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.800111.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(93)90092-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00197-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.1973"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00663-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01572-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00063-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200002000-00013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(90)90068-J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00350-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00153-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(92)90103-N"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(91)90209-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(94)90260-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.003431"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/76760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:14:50Z","timestamp":1745468090000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000076760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2004,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000076760","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}