{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:08:59Z","timestamp":1745554139709,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To assess the significance of cyclo-oxygenase 2 (COX-2) in laryngeal squamous cell carcinoma (LSCC). &lt;i&gt;Study Design:&lt;\/i&gt; An immunohistochemical study in which 39 patients with LSCC were included. &lt;i&gt;Methods:&lt;\/i&gt; Immunohistochemical staining of the paraffin-embedded tumour tissues was performed using isoform-specific COX-2 polyclonal antisera (Santa Cruz, Calif., USA). COX-2 results were compared with the clinical parameters of the patients. &lt;i&gt;Results:&lt;\/i&gt; COX-2 was detected in all tumour tissues. In the normal laryngeal tissue around the tumour area, which served as control, there was no COX-2 staining. There was no relationship between the COX-2 results and the location of the primary tumour, T stage and N stage, survival, recurrence or pulmonary metastases. &lt;i&gt;Conclusion:&lt;\/i&gt; The absence of a relation between COX-2 positivity and clinical parameters may suggest an involvement of COX-2 in laryngeal carcinogenesis. Since COX-2 positivity could be detected in all LSCC specimens studied, COX-2 could serve as a therapeutic target in LSCC.<\/jats:p>","DOI":"10.1159\/000077797","type":"journal-article","created":{"date-parts":[[2004,5,28]],"date-time":"2004-05-28T08:45:10Z","timestamp":1085733910000},"page":"65-69","source":"Crossref","is-referenced-by-count":13,"title":["Cyclo-Oxygenase 2 Expression in Laryngeal Squamous Cell Carcinoma and Its Clinical Correlates"],"prefix":"10.1159","volume":"66","author":[{"given":"Y\u0131ld\u0131r\u0131m A.","family":"Bayaz\u0131t","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman","family":"Buyukberber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"Sar\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celalettin","family":"Camc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enver","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Sevinc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metin","family":"Karakok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzaffer","family":"Kanl\u0131kama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semih","family":"Mumbuc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00488-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1607"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90127-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20011120)95:6<343::AID-IJC1060>3.0.CO;2-D"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00050-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(02)00025-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199907000-00025"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(84)90171-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200202000-00008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600183"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200205000-00012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10108"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.125376"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3336"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/77797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/77797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:07:42Z","timestamp":1745464062000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000077797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000077797","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"type":"print","value":"0301-1569"},{"type":"electronic","value":"1423-0275"}],"subject":[],"published":{"date-parts":[[2004]]}}}