{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:08:59Z","timestamp":1745554139950,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; A trend towards a decrease in gonorrhea in Japan was observed until the mid-1990s, but soon after that period, an increased incidence of gonorrhea was reported. &lt;i&gt;Methods:&lt;\/i&gt; Antimicrobial susceptibility, auxotype and the type of &lt;i&gt;gyrA&lt;\/i&gt; and &lt;i&gt;parC&lt;\/i&gt; mutations were compared between 200 and 132 &lt;i&gt;Neisseria gonorrhoeae&lt;\/i&gt; isolates from male and female patients with gonorrhea, respectively. &lt;i&gt;Results and Conclusion:&lt;\/i&gt; The isolation frequency of ciprofloxacin-resistant isolates from male patients was higher than that from female patients (19.5 and 13.6%, respectively). All ciprofloxacin-resistant isolates had single to triple mutations in &lt;i&gt;gyrA&lt;\/i&gt; and\/or &lt;i&gt;parC&lt;\/i&gt; genes. &lt;i&gt;N. gonorrhoeae &lt;\/i&gt;isolates showed a predominance of Pro-requiring auxotypes (46.5 and 46.2% of the isolates from male and female patients, respectively). Of the Pro-requiring isolates, the incidence of ciprofloxacin-resistant isolates was higher in the isolates from male patients than in the isolates from female patients.<\/jats:p>","DOI":"10.1159\/000077809","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T18:30:54Z","timestamp":1087842654000},"page":"92-97","source":"Crossref","is-referenced-by-count":2,"title":["A Comparison of the Microbiological Characteristics of &lt;i&gt;Neisseria gonorrhoeae&lt;\/i&gt; Isolated from Male and Female Patients with Gonorrhea"],"prefix":"10.1159","volume":"50","author":[{"given":"Takeshi","family":"Saika","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Intetsu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matsuhisa","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199711000-00005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2543-2544.2000"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/77809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/77809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:07:53Z","timestamp":1745464073000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000077809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":2,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000077809","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2004]]}}}