{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:47:19Z","timestamp":1781822839481,"version":"3.54.5"},"reference-count":3,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Objective:<\/i> The primary objective of the study was to determine the prevalence of brucellosis and the antimicrobial susceptibility pattern of local <i>Brucellae<\/i> isolates in the Infectious Diseases Hospital, Kuwait. <i>Subjects and Methods:<\/i> A single serum sample was collected from each of 1,836 patients of different nationalities from January 2000 to December 2001. Any patient with a provisional diagnosis of fever or brucellosis had a standard tube agglutination (STA) test for the quantitation of <i>Brucella<\/i> antibodies. Blood cultures were done in 166 of 455 patients with significant STA titers, using the Bactec system. Antimicrobial susceptibility testing of 123 isolates of <i>Brucella<\/i> spp. was done against 8 antimicrobial agents. <i>Results:<\/i> A total of 455 serum samples (24.8%) having an STA titer of \u22671:160 were presumptively diagnosed as cases of brucellosis. The peak isolation was in April and May. <i>Brucella<\/i> spp. were isolated from 123 blood cultures (74.1%). The blood culture isolation rate was significantly higher in patients with an STA titer of \u22671:1,280 than in those with an STA titer of \u22641:160 (p < 0.05). Antimicrobial susceptibility testing showed good in vitro activity of tetracycline, gentamicin, amikacin, streptomycin and ciprofloxacin against all isolates. Azithromycin had good anti-<i>Brucella<\/i> activity against only 42% of the isolates, while rifampicin and trimethoprim-sulfamethoxazole showed low in vitro anti-<i>Brucella<\/i> activity against 8 and 25% of the isolates, respectively. <i>Conclusion:<\/i> Brucellosis is quite common in Kuwait. Kuwaiti and Bangladeshi nationals were most affected. Significant titers on the STA test were detected in 24.8% of serum samples. Good in vitro activity against all isolates was found with tetracycline, gentamicin, amikacin, ciprofloxacin and streptomycin, and low activity with azithromycin, rifampicin and trimethoprim-sulfamethoxazole.<\/jats:p>","DOI":"10.1159\/000078319","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T07:33:23Z","timestamp":1086766403000},"page":"215-219","source":"Crossref","is-referenced-by-count":12,"title":["Seroepidemiological and Microbiological Study of Brucellosis in Kuwait"],"prefix":"10.1159","volume":"13","author":[{"given":"Ts.","family":"Dimitrov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Panigrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Emara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Awni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Passadilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00016-4.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(92)90575-W"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(86)90118-5"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:13:03Z","timestamp":1745464383000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000078319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":3,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2004,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000078319","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}