{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:18:26Z","timestamp":1785842306400,"version":"3.56.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>We analyzed genetic changes in condylomas (four cases), vulvar intraepithelial neoplasia I\u2013III (VIN I\u2013III, eleven cases), and primary vulvar squamous cell carcinomas (VSCC, ten cases) by high-resolution comparative genomic hybridization (HR-CGH) and flowcytometry. All samples were also human papilloma virus (HPV)-genotyped. Gain of chromosome 1, the aberration most often seen in VIN III (67%), was not seen in HPV-positive or -negative VSCCs (0%). Both VIN III and VSCC frequently showed gain of 3q (56 and 70%, respectively). The VIN III samples often demonstrated gain of 20q (56%) and 20p (44%), and the VSCC samples gain of 8q (60%), loss of 3p (50%), and 8p (40%). None of the four most frequent changes in the VSCC samples occurred exclusively in the HPV-positive or -negative samples. As expected, we did not find any cytogenetic changes in condylomas and nearly any changes in VIN I\u2013II.\u00a0\u00a0\u00a0<\/jats:p>","DOI":"10.1159\/000078559","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T18:30:54Z","timestamp":1087842654000},"page":"43-48","source":"Crossref","is-referenced-by-count":14,"title":["The most common chromosome aberration detected by high-resolution comparative genomic hybridization in vulvar intraepithelial neoplasia is not seen in vulvar squamous cell carcinoma"],"prefix":"10.1159","volume":"106","author":[{"given":"T.","family":"Bryndorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kirchhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Andreasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bjerregaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Westh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lundsteen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.2001.6466"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6600112"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00006250-199203000-00025"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2890%2990186-I"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fcyto.990120705"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.93.1.479"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.1994.1039"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fmodpathol.3880321"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2897%2900298-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1359641"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0320%2819970601%2928%3A2%3C130%3A%3AAID-CYTO5%3E3.0.CO%3B2-J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0320%2819980301%2931%3A3%3C163%3A%3AAID-CYTO3%3E3.0.CO%3B2-M"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2264%28199908%2925%3A4%3C410%3A%3AAID-GCC17%3E3.0.CO%3B2-J"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2264%28199902%2924%3A2%3C144%3A%3AAID-GCC7%3E3.0.CO%3B2-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2801%2900424-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.1999.5632"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0029-7844%2895%2900101-V"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1006%2Fgyno.2000.5739"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.1549"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:14:56Z","timestamp":1745464496000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000078559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000078559","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"value":"1424-8581","type":"print"},{"value":"1424-859X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}