{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:35:15Z","timestamp":1768440915369,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopathology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Although previous reports have described the association of autism, mental retardation, and schizophrenia with a missing Y chromosome, we are not aware of any case showing an association between this particular chromosomal abnormality and Asperger syndrome. &lt;i&gt;Method:&lt;\/i&gt; We report the case of a male patient with a combination of Asperger syndrome, obsessive-compulsive disorder and 45,X\/46,XY mosaicism. During the follow-up, this individual has also developed a severe episode of major depression, which was successfully treated with electroconvulsive therapy. &lt;i&gt;Results:&lt;\/i&gt; To the best of our knowledge, this is the first case in which a 45,X\/46,XY mosaicism was described in association with Asperger syndrome, either alone or associated with other psychiatric disorders. Diagnostic and therapeutic aspects of this unique case are presented and discussed. &lt;i&gt;Conclusions:&lt;\/i&gt; Our findings suggest that a missing Y chromosome may play an etiological role in some cases of Asperger syndrome.<\/jats:p>","DOI":"10.1159\/000078608","type":"journal-article","created":{"date-parts":[[2004,5,19]],"date-time":"2004-05-19T08:42:44Z","timestamp":1084956164000},"page":"105-109","source":"Crossref","is-referenced-by-count":20,"title":["Asperger Syndrome, Obsessive-Compulsive Disorder, and Major Depression in a Patient with 45,X\/46,XY Mosaicism"],"prefix":"10.1159","volume":"37","author":[{"given":"Leonardo F.","family":"Fontenelle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro V.","family":"Mendlowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Bezerra de Menezes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Rita","family":"dos Santos Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio","family":"Versiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199912001-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/35103559"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1998.00091.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005523232106"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/08039480152036047"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00121-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(01)80105-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90300-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016330802348"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005555624566"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S001216229900167X"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.2.304"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000968"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00299-1"}],"container-title":["Psychopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:15:54Z","timestamp":1745464554000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000078608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000078608","archive":["Portico"],"relation":{},"ISSN":["0254-4962","1423-033X"],"issn-type":[{"value":"0254-4962","type":"print"},{"value":"1423-033X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}