{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:34:37Z","timestamp":1791128077095,"version":"4.1.0"},"reference-count":89,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>Chemical haptens and metal ions interact with proteins and thereby become recognizable by T and B lymphocytes. They induce the production of proinflammatory cytokines and chemokines by various cell types due to triggering of innate immune responses. This is an important prerequisite for the activation of the adaptive immune system and the development of diseases like allergic contact dermatitis and adverse drug and autoimmune reactions. Our increasing knowledge about the molecular basis of hapten and metal ion recognition by T cells and about the pathomechanisms of contact hypersensitivity and chemical-induced autoimmune reactions allows concomitant progress in the development of modern strategies for immunotherapy and will hopefully enable more specific intervention in hapten- and metal ion-induced human diseases in the future.<\/jats:p>","DOI":"10.1159\/000078765","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T07:33:23Z","timestamp":1086766403000},"page":"186-198","source":"Crossref","is-referenced-by-count":96,"title":["T Lymphocyte-Mediated Immune Responses to Chemical Haptens and Metal Ions: Implications for Allergic and Autoimmune Disease"],"prefix":"10.1159","volume":"134","author":[{"given":"Stefan F.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80076-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.369"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.12.1755"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.2.739"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.1.145"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01289-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.600501.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90103-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/351290a0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80006-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80007-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/348213a0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90490-H"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.120110.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00306.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.1.229"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.2.768"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90037-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90038-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1053\/ajcd.2000.7187"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00490-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200106000-00006"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2001.5053"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021762"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030121"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(98)00106-0"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01513.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12031.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(93)90017-V"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12363337"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00013-5"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12343589"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/48.1.74"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.6.1654"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00678.x"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00916.x"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00087.x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01791.x"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207326200"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12065.x"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.12.1.991"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1038\/90609"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20001858"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00105-6"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01847.x"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01022-2"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2000.009003165.x"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.109832"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470107.x"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(01)01944-3"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(00)01815-9"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118796"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.1001"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep13070998"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00334.x"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12289700"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1385\/IR:24:1:69"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1089\/10799900252952181"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.5.779"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371697"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00105.x"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02230-5"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200105)31:5<1582::AID-IMMU1582>3.0.CO;2-M"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1159\/000049499"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1159\/000064537"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.10.1803"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3706::AID-IMMU3706>3.0.CO;2-7"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01146.x"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.759"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0727"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1038\/84298"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00067.x"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200205)32:5<1445::AID-IMMU1445>3.0.CO;2-E"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215988"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1038\/nature01726"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031244"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021348"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011502"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1038\/89726"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2002.110518.x"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-117"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe020157"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00338-2"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319220"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-366"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200211)32:11<3171::AID-IMMU3171>3.0.CO;2-4"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200322919"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1570"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:17:39Z","timestamp":1745464659000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000078765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":89,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000078765","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}