{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:37:10Z","timestamp":1761154630358,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Paragonimiasis westermani (Pw), a common parasitic zoonosis in Asia, is typically associated with eosinophilia. Th2 cytokines seem to have an important role in the clinical manifestations of this disease. Thymus and activation-regulated chemokine (TARC) is a potential key regulator of Th2-mediated inflammation. The purpose of the present study was to evaluate the antigen-specific Th2-dominant responses in patients with Pw. &lt;i&gt;Methods:&lt;\/i&gt; The concentrations of cytokines and chemokines in supernatants of peripheral blood mononuclear cell (PBMC) cultures with or without antigen stimulation were measured by enzyme-linked immunosorbent assay (ELISA). TARC levels in serum from Pw patients were also evaluated by ELISA. The number of Th2 cells expressing the CC-chemokine receptor 4 (CCR4) in the peripheral blood was evaluated by flow cytometry. &lt;i&gt;Results:&lt;\/i&gt; Antigen-stimulation induced production of IL-5 and IL-13, but not IFN-\u03b3 from PBMC cultures in patients with Pw. Pw patients had elevated serum TARC levels and a higher proportion of CCR4-expressing cells among CD4+ T cells in the peripheral blood. There were also higher levels of TARC, but not IP-10, in supernatants of antigen-stimulated PBMC culture compared to unstimulated PBMC culture in patients with Pw. &lt;i&gt;Conclusion:&lt;\/i&gt; Our findings clarify antigen-specific Th2-dominant responses in patients with Pw and suggest a possible role for TARC in Th2-dominant responses.<\/jats:p>","DOI":"10.1159\/000078773","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T07:33:23Z","timestamp":1086766403000},"page":"248-252","source":"Crossref","is-referenced-by-count":5,"title":["A Possible Role of TARC in Antigen-Specific Th2-Dominant Responses in Patients with Paragonimiasis westermani"],"prefix":"10.1159","volume":"134","author":[{"given":"Shigeki","family":"Katoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Tokojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ichi","family":"Ashitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukumi","family":"Nakamura-Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Matsushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Matsukura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukifumi","family":"Nawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(98)00057-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01425.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.35.21514"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.23.15036"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.1.129"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.6.875"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00149.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00277.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.1.399"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01985.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126079"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126378"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1979"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78773","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/78773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:17:46Z","timestamp":1745464666000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000078773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000078773","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2004]]}}}