{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:00:23Z","timestamp":1759683623393,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>There is evidence that children with antisocial behaviors have increased plasma levels of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) and either a decreased level of another adrenal steroid, cortisol, or a decreased cortisol responsivity to stress. Low levels of cortisol have also been reported in antisocial adults but their levels of DHEA-S have not been studied. The present study was designed to perform in adult cocaine addicts simultaneous assessments of DHEA-S and cortisol as a function of a diagnosis of antisocial personality disorder (adult symptoms) and of a retrospective diagnosis of conduct disorder (CD). Basal cortisol and DHEA-S were determined in the plasma samples of 40 hospitalized men. The patients\u2019 cortisol responsivity was also assessed while they were being exposed to a stressful situation. Patients who had a retrospective CD diagnosis had significantly increased DHEA-S levels and secreted less cortisol when stressed. Comparisons between patients who did and did not meet the antisocial personality disorder adult criteria did not reveal any significant difference in DHEA-S or in cortisol responsivity. This could be attributed to the nature of the criteria used to define the adult disorder, which focus mostly on a failure to conform to social norms, whereas a number of CD criteria involve displays of some degree of violence. In conclusion, adults who retrospectively qualified for a CD diagnosis had increased DHEA-S levels and a decreased cortisol reactivity, confirming observations made in children and indicating that mechanisms underlying adrenal steroid alterations in childhood could still be at play in adulthood.<\/jats:p>","DOI":"10.1159\/000079109","type":"journal-article","created":{"date-parts":[[2004,7,30]],"date-time":"2004-07-30T09:16:15Z","timestamp":1091178975000},"page":"161-166","source":"Crossref","is-referenced-by-count":20,"title":["Cocaine Addicts with Conduct Disorder Are Typified by Decreased Cortisol Responsivity and High Plasma Levels of DHEA-S"],"prefix":"10.1159","volume":"50","author":[{"given":"Laure","family":"Buydens-Branchey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Branchey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.1.38"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(93)90108-S"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.3.297"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200011000-00019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00382-D"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00216-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(92)90025-A"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(94)90114-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200011000-00020"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000054881"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(90)85151-K"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.4.1002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.4.1086"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.6.1542"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.9.3141"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03171-7"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:20:28Z","timestamp":1745464828000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000079109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000079109","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"type":"print","value":"0302-282X"},{"type":"electronic","value":"1423-0224"}],"subject":[],"published":{"date-parts":[[2004]]}}}