{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:35:06Z","timestamp":1782902106637,"version":"3.54.5"},"reference-count":11,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Background:<\/i> Hydatid disease of the liver though endemic in many countries, is rare in the UK. We evaluated a 16-year experience of treating hydatidosis using a management protocol combining surgery with anti-scolicidals. <i>Patients and Methods:<\/i> There were 30 patients. 14 (47%) males, median age 41 (range 25\u201372) years, of whom 21 (70%) were symptomatic. Diagnosis was by serological tests and imaging. All had disease confined to the liver and received peri-operative anti-scolicidal drug therapy. <i>Results:<\/i> The initial 4 (13%) patients received praziquantel combined with albendazole for 2 weeks and the following 26 (87%) patients received two cycles of albendazole 400 mg twice daily for 28 days, with a 14-day break in between. However, 2 (7%) patients could not tolerate albendazole, one due to GI side effects and the other developed deranged liver functions. These 2 patients subsequently received praziquantel for 2 weeks. All patients underwent surgery. Subtotal cystectomy was carried out on 29 (96%) patients and 1 patient required a segmentectomy. Cystobiliary communications were identified in 15 (50%) of patients which were oversewn using fine absorbable sutures. Of these, 7 had the bile ducts decompressed using a T tube, with only 1 developing a post-operative bile leak. In comparison, 8 were not drained of which 6 leaked (p = 0.03). The median post-operative hospital stay was 8 days (range 5\u201324). Patients who developed post-operative bile leaks, however, needed prolonged abdominal drainage for a median of 21 days (range 18\u201324). Two (7%) patients developed histologically proven recurrent disease. The median follow-up was 56 months (range 3\u201387). <i>Conclusion:<\/i> Surgery combined with anti-scolicidal therapy proved effective. Cystobiliary communications are common and, when identified, should result in the biliary system being drained, to avoid post-operative bile leaks.<\/jats:p>","DOI":"10.1159\/000079492","type":"journal-article","created":{"date-parts":[[2004,7,5]],"date-time":"2004-07-05T15:11:53Z","timestamp":1089040313000},"page":"227-234","source":"Crossref","is-referenced-by-count":28,"title":["Treatment of Hydatid Disease of the Liver"],"prefix":"10.1159","volume":"21","author":[{"given":"M.A.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.F.","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"Bramhall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.D.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"McMaster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.C.","family":"Buckels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2883%2992533-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01659061"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01655892"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800650407"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199709253371303"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9610%2802%2900877-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchsurg.134.2.166"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-198404000-00007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.285.6336.175"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.28.1.75"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004649910014"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:24:34Z","timestamp":1745465074000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000079492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000079492","archive":["Portico"],"relation":{},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"value":"0253-4886","type":"print"},{"value":"1421-9883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}