{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:54:30Z","timestamp":1773280470900,"version":"3.50.1"},"reference-count":5,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>This study investigated the efficiency of a chlorhexidine varnish and an antibiotic paste in suppressing the cultivable microflora of deep dentine cavities in a stepwise excavation procedure. Subsequent to enamel preparation and removal of the central biomass, infected dentine was sampled from the cavity floor. Ten cavities each were either covered with the 1% chlorhexidine- and 1% thymol-containing varnish Cervitec (CE), the demeclocycline hydrocortisone-containing ointment Ledermix (LE) or received no treatment as control (CO). A compomer composite was used as intermediate restorative. Cavities were reassessed after 6 weeks and again dentine samples were microbiologically investigated for total viable counts, mutans streptococci and lactobacilli. After 6 weeks a significant reduction of the total viable counts was observed in the LE group (p = 0.011) compared to the control, whereas no differences were found in the CE group (p &gt; 0.05). Mutans streptococci were rarely recovered at baseline and after 6 weeks. Compared to the CO group counts of lactobacilli were significantly reduced in the CE and LE groups (p &lt; 0.05). Lactobacillus species were frequently recovered at baseline and after 6 weeks of observation. &lt;i&gt;Lactobacillus rhamnosus&lt;\/i&gt; was the predominant species in all samples investigated. Application of CE or LE resulted in reduced counts of lactobacilli after a period of 6 weeks. Although none of the materials completely eliminated the viable microorganisms, the use of LE was more effective than CE in reducing the total anaerobic microorganisms associated with carious dentine.<\/jats:p>","DOI":"10.1159\/000079624","type":"journal-article","created":{"date-parts":[[2004,8,23]],"date-time":"2004-08-23T08:31:08Z","timestamp":1093249868000},"page":"436-441","source":"Crossref","is-referenced-by-count":29,"title":["Suppression of Caries-Related Microorganisms in Dentine Lesions after Short-Term Chlorhexidine or Antibiotic Treatment"],"prefix":"10.1159","volume":"38","author":[{"given":"Michael J.","family":"Wicht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Haak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Sch\u00fctt-Gerowitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Kneist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Noack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000016631"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000016572"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(73)90109-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000016601"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(85)90063-6"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:26:37Z","timestamp":1745465197000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000079624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":5,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2004,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000079624","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}