{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:03:19Z","timestamp":1760547799265,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; Detrusor overactivity and urethral sphincter pseudodyssynergia may develop during recovery from cerebrovascular accidents or intracranial lesions, resulting in difficulty in urination, a large amount of residual urine, and recurrent urinary tract infection. This study evaluated the effectiveness of urethral injection of botulinum A toxin in treating these patients. &lt;i&gt;Methods:&lt;\/i&gt; Twenty-one patients with chronic cerebrovascular accidents or intracranial lesions and difficult urination were enrolled. Patients participating in the study elected to receive either 100 units of botulinum A toxin (n = 11) or served as medically treated controls (n = 10). The urodynamic parameters and voiding efficiency after treatment were compared between the 2 groups. &lt;i&gt;Results:&lt;\/i&gt; An excellent result was obtained in 6 patients and an improved result in 4 patients, resulting in an overall success rate of 91% in the study group. Four patients with frank urinary retention before treatment resumed spontaneous voiding. The maximal effects of botulinum A toxin appeared about 2 weeks after treatment. The voiding pressure decreased (57.8 \u00b1 35.2 vs. 33.8 \u00b1 16.9 cm H&lt;sub&gt;2&lt;\/sub&gt;O, p = 0.005) and the maximal flow rate increased (7.2 \u00b1 5.9 vs. 10.3 \u00b1 5.2 ml\/s, p = 0.005) significantly. In the control group, 4 patients (40%) had spontaneous voiding 6 months after medical treatment, whereas 6 patients remained unchanged requiring an indwelling Foley catheter (n = 2) or clean intermittent catheterization (n = 4). The symptom score and the quality of life index showed significantly greater improvement in the study group than in the control group. &lt;i&gt;Conclusion:&lt;\/i&gt; This study demonstrates that urethral injection of botulinum A toxin is effective and without adverse effects in the treatment of patients with urethral sphincter pseudodyssynergia after cerebrovascular accidents or the development of intracranial lesions.<\/jats:p>","DOI":"10.1159\/000079697","type":"journal-article","created":{"date-parts":[[2004,8,23]],"date-time":"2004-08-23T08:31:08Z","timestamp":1093249868000},"page":"156-162","source":"Crossref","is-referenced-by-count":28,"title":["Botulinum A Toxin Treatment of Urethral Sphincter Pseudodyssynergia in Patients with Cerebrovascular Accidents or Intracranial Lesions"],"prefix":"10.1159","volume":"73","author":[{"given":"Yue Hwa","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hann-Chorng","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,8,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00322-S"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199603000-00064"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s003450050094"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(1997)16:1<1::AID-NAU1>3.3.CO;2-C"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200104000-00011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199611000-00054"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(83)90099-7"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:26:59Z","timestamp":1745465219000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000079697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000079697","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2004]]}}}