{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:46:11Z","timestamp":1790664371827,"version":"4.1.0"},"reference-count":5,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Alloantigen-specific and unspecific immune processes contribute to chronic renal graft dysfunction. Despite \u2018optimized immunosuppressive therapy\u2019 (IS), the role of chronic cell activation still remains open. &lt;i&gt;Methods:&lt;\/i&gt; 69 kidney transplant recipients (NTX) were assessed for monocyte surface antigens CD14 (LPS receptor) and CD16 (Fc-\u03b3-III receptor) by flow cytometry including the percentage amount of the proinflammatory CD14+CD16+ subset. 14 non-dialysis patients with chronic renal failure (CRF) and 24 healthy persons served as controls. &lt;i&gt;Results:&lt;\/i&gt; All 14 patients suffering from CRF revealed &lt;i&gt;higher CRP&lt;\/i&gt; serum levels compared to healthy controls (p = 0.01). NTX patients had a (not significant) tendency to higher&lt;i&gt; CRP&lt;\/i&gt; concentrations (p &gt; 0.05). The mean &lt;i&gt;expression of CD14&lt;\/i&gt; on monocytes (mCD14) was &lt;i&gt;lower&lt;\/i&gt; in patients with CRF and in NTX patients (p = 0.024 \u2013 p = 0.026). NTX patients revealed low expression of monocytic CD14 with no difference between the single IS therapy groups. The &lt;i&gt;proinflammatory&lt;\/i&gt; monocyte subpopulation positive for CD14 and CD16 was elevated both in uremic and NTX patients (p &lt; 0.002), despite long-lasting IS therapy. &lt;i&gt;Conclusions:&lt;\/i&gt; Continuing IS therapy, even under \u2018optimized\u2019 drug-monitoring conditions, &lt;i&gt;does not&lt;\/i&gt; sufficiently prevent or suppress a microinflammatory (and potential fibrotic growth-promoting) status in NTX patients.<\/jats:p>","DOI":"10.1159\/000079807","type":"journal-article","created":{"date-parts":[[2004,7,19]],"date-time":"2004-07-19T06:45:27Z","timestamp":1090219527000},"page":"177-180","source":"Crossref","is-referenced-by-count":14,"title":["Impact of Different Immunosuppressive Regimens on Antigen-Presenting Blood Cells in Kidney Transplant Patients"],"prefix":"10.1159","volume":"27","author":[{"given":"Juergen E.","family":"Scherberich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Estner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Segerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011295"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200114142"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200006150-00045"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199811000-00006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013036"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/79807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:27:31Z","timestamp":1745465251000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000079807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000079807","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}