{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:32:10Z","timestamp":1790857930425,"version":"4.1.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2004]]},"abstract":"We studied tracer distributions in positron emission tomography of ligands for dopamine D<sub>1<\/sub> receptors ([<sup>11<\/sup>C]SCH23390) and D<sub>2<\/sub> receptors ([<sup>11<\/sup>C]raclopride) and the dopamine precursor analog 6-[<sup>18<\/sup>F]fluoro-<i>L<\/i>-3,4-dihydroxyphenylalanine ([<sup>18<\/sup>F]FDOPA), as a measurement of presynaptic dopaminergic function, in the brain after 6-hydroxydopamine lesioning of the medial forebrain bundle in rats. The unilateral lesions were confirmed behaviorally by methamphetamine-induced rotation 2 weeks after lesioning, and the brains were analyzed by tissue dissection following an intravenous bolus of each tracer 3 weeks after lesioning. [<sup>11<\/sup>C]Raclopride, but not [<sup>11<\/sup>C]SCH23390, showed a higher accumulation in the striatum on the lesion side compared with that on the non-lesioned (intact) side. On the other hand, a lower accumulation of [<sup>18<\/sup>F]FDOPA was found in the striatum and cerebral cortex on the lesion side. Our studies demonstrate upregulation of dopamine D<sub>2<\/sub> receptors in the striatum and a decrease in FDOPA uptake in both the striatum and cerebral cortex ipsilateral to the 6-hydroxydopamine lesions. Therefore, the combination of a D<sub>2<\/sub> antagonist and FDOPA may provide a potentially useful method for assessing the effects of dopamine depletion in Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1159\/000080051","type":"journal-article","created":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T06:36:52Z","timestamp":1097476612000},"page":"109-112","source":"Crossref","is-referenced-by-count":9,"title":["Changes in Dopamine D<sub>2<\/sub> Receptors and 6-[<sup>18<\/sup>F]Fluoro-<i>L<\/i>-3,4-Dihydroxyphenylalanine Uptake in the Brain of 6-Hydroxydopamine- Lesioned Rats"],"prefix":"10.1159","volume":"1","author":[{"given":"Yasushi","family":"Ishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Magata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichiro","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hashiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Saji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0020-708X%2873%2990008-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2F305137a0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2883%2991187-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-2999%2868%2990164-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2897%2901541-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2898%2900874-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2870%2990187-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2880%2991093-8"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F1096-9861%2820001120%29427%3A3%3C440%3A%3AAID-CNE10%3E3.0.CO%3B2-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.1966.tb09873.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-4886%2891%2990095-T"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0891-0618%2895%2900064-E"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-2999%2886%2990072-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2887%2990449-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-977X%2800%2900094-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2898%2900248-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F124.6.1125"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.57.4.470"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2873%2990776-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1986.65.2.0135"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:30:34Z","timestamp":1745465434000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":20,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2004,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080051","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}