{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:52:24Z","timestamp":1776995544983,"version":"3.51.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The National Kidney Foundation has recently published the Kidney Disease Outcomes Quality Initiative (K\/DOQI) Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease (CKD). According to these guidelines, in patients with stage 5 CKD, the adjusted calcium level should be 8.4\u2013 9.5 mg\/dl, the serum phosphate should be 3.5\u20135.5 mg\/dl, the calcium phosphorous product should be &lt;55 mg&lt;sup&gt;2&lt;\/sup&gt;\/dl&lt;sup&gt;2&lt;\/sup&gt; and the intact parathyroid hormone (PTH) level should be 150\u2013300 pg\/ml. &lt;i&gt;Methods:&lt;\/i&gt; In order to evaluate our ability to meet these targets, we reviewed laboratory parameters of bone and mineral metabolism of 140 patients over a 6-month period in an inner city hemodialysis unit. Serum calcium and phosphate levels were determined using standard assays and PTH levels were determined using the Nichols Intact PTH assay. &lt;i&gt;Results:&lt;\/i&gt; We found that the levels of serum calcium and serum phosphorus fell within the range recommended by the K\/DOQI guidelines 49 and 36% of the time respectively. 57% of the determinations for calcium \u00d7 phosphorus product were &lt;55 mg&lt;sup&gt;2&lt;\/sup&gt;\/dl&lt;sup&gt;2&lt;\/sup&gt;. PTH levels were within the recommended values in 20% of the determinations. Only 7% of the determinations met all four criteria simultaneously in spite of meeting other K\/DOQI targets such as hematocrit and dialysis adequacy. &lt;i&gt;Conclusion:&lt;\/i&gt; These data indicate that current practice for the management of bone and mineral metabolism in hemodialysis falls far short of meeting the K\/DOQI guidelines.<\/jats:p>","DOI":"10.1159\/000080087","type":"journal-article","created":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T13:02:27Z","timestamp":1092315747000},"page":"422-426","source":"Crossref","is-referenced-by-count":47,"title":["Achieving K\/DOQI Laboratory Target Values for Bone and Mineral Metabolism: An Uphill Battle"],"prefix":"10.1159","volume":"24","author":[{"given":"Ziyad","family":"Al Aly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther A.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Gellens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.1998.v31.pm9531176"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2800%2970064-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2803%2900826-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00041552-200109000-00003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200005183422003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000056344"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F14.12.2907"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:30:44Z","timestamp":1745465444000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2004,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080087","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}