{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:11Z","timestamp":1745554211770,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>After a peripheral nerve injury, ion channel organization and the electrical properties of nerve fibers drastically change during the regeneration process. The present study was designed to compare the frequency-dependent characteristics of regenerating nerves in the presence of 4-aminopyridine (4-AP) and tetraethylammonium (TEA). The results showed that increasing the stimulus frequency produced a greater impulse blockade (frequency-dependent block \u2013 FDB) and distinct hyperpolarizing afterpotentials (HAPs) in regenerating nerves. In particular, regenerating sciatic nerves 15 days post-crush (dpc) were more sensitive to the frequency-dependent stimulations than 38-dpc and intact nerves in the presence or absence of drugs. The frequency-dependent effects of TEA on the compound action potentials (CAPs) appeared when TEA was applied to 4-AP-treated nerves. This shows that TEA-sensitive channels may not be masked by the myelin. 4-AP was here found to have more pronounced frequency-dependent effects on regenerating nerves than on intact nerves. Delayed depolarization (in 38-dpc: 22.6 \u00b1 1.3 mV and 47.52 \u00b1 3.63 ms, in intact: 12.0 \u00b1 1.9 mV and 88.51 \u00b1 4.72 ms) elicited by 4-AP resulted in an increase in FDBs and HAP amplitudes. These results suggest that 4-AP-sensitive channels may play important roles in frequency-dependent nerve conduction. Consequently, regenerating or myelin damaged nerves are more sensitive to repetitive firing with or without drug. An understanding of the frequency-dependent properties of regenerating nerves may be of value in the treatment of the nerve diseases.<\/jats:p>","DOI":"10.1159\/000080100","type":"journal-article","created":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T06:36:52Z","timestamp":1097476612000},"page":"157-166","source":"Crossref","is-referenced-by-count":11,"title":["Role of Potassium Channels in the Frequency-Dependent Activity of Regenerating Nerves"],"prefix":"10.1159","volume":"72","author":[{"given":"Tufan","family":"Mert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Gunay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf Kenan","family":"Daglioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(96)01042-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00049-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81133-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90112-H"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000072358"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0326"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199808)21:8<1040::AID-MUS8>3.0.CO;2-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00138-9"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:30:48Z","timestamp":1745465448000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080100","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2004]]}}}