{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:17:49Z","timestamp":1762100269994,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Objective:<\/i> To investigate the relationship between unexplained elevated second-trimester free \u03b2-human chorionic gonadotropin (\u03b2-hCG) levels and pregnancy complications as well as adverse pregnancy outcomes. <i>Methods:<\/i> The study cohort comprised 2,110 non-smoking women with chromosomal and structurally normal fetuses at low-risk for both Down\u2019s syndrome (risk <1:250) and neural tube defects (maternal serum \u03b1-fetoprotein <2.0 MoM). A free \u03b2-hCG value of \u22672.0 MoM was used to define the populations with elevated levels of free \u03b2-hCG. Descriptive statistics, \u03c7<sup>2<\/sup> test, Fisher\u2019s exact test, and logistic regression analysis were used for statistical analysis, and p < 0.05 was considered statistically significant. <i>Results:<\/i> The mean maternal age of the study group was significantly lower than in controls (27.9 \u00b1 4.3 and 30.6 \u00b1 5.1 years, respectively, p < 0.05), while the proportion of primigravidas was significantly higher compared to that of controls (p < 0.05). After adjustment of the 2 groups according to maternal age and parity, we observed an increased incidence of preeclampsia among women with elevated free \u03b2-hCG levels in relation to controls (p < 0.05). However, a logistic regression analysis demonstrated that the free \u03b2-hCG level was not a predictor of the occurrence of preeclampsia. No significant relationship was found with the incidence of gestational diabetes, oligohydramnios, polyhydramnios, pregnancy-related hypertension, intrauterine growth retardation, preterm delivery, spontaneous abortion and stillbirths (p > 0.05).<\/jats:p>","DOI":"10.1159\/000080159","type":"journal-article","created":{"date-parts":[[2004,11,9]],"date-time":"2004-11-09T07:56:35Z","timestamp":1099986995000},"page":"483-487","source":"Crossref","is-referenced-by-count":5,"title":["Elevated Second-Trimester Free \u03b2-hCG as an Isolated Finding and Pregnancy Outcomes"],"prefix":"10.1159","volume":"19","author":[{"given":"Bojana","family":"Brajenovi\u0107-Mili\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dubravka","family":"Ti\u0161lari\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"\u017duvi\u0107-Butorac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josip","family":"Ba\u010di\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Petrovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smiljana","family":"Risti\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Mimica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miljenko","family":"Kapovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0029-7844%2895%2900390-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199711%2917%3A11%3C1027%3A%3AAID-PD188%3E3.3.CO%3B2-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1999.13010058.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2897%2900088-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0223%28200008%2920%3A8%3C652%3A%3AAID-PD882%3E3.3.CO%3B2-Y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199902%2919%3A2%3C122%3A%3AAID-PD491%3E3.0.CO%3B2-R"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2897%2900151-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000020871"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0029-7844%2895%2900108-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-5456%2800%2900137-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199803%2918%3A3%3C225%3A%3AAID-PD239%3E3.0.CO%3B2-B"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000047999"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2800%2901109-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0020-7292%2896%2902830-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000188939"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199903%2919%3A3%3C219%3A%3AAID-PD512%3E3.0.CO%3B2-K"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109%2F10641959309031050"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:31:54Z","timestamp":1745465514000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2004,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080159","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2004]]}}}