{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:50:34Z","timestamp":1761580234968,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2004]]},"abstract":"<i>Objectives:<\/i> The 10-\u00b5g gonadotropin-releasing hormone (GnRH) test assesses pituitary gonadotroph responsiveness, whereas the 100-\u00b5g dose assesses maximal secretory capacity. Our aims were to establish normative data for the low-dose test in children and to evaluate the test in diagnosing common pubertal disorders. <i>Methods:<\/i> We retrospectively classified 107 children who underwent 10-\u00b5g GnRH tests into normal prepubertal (20 boys, 10 girls), normal early pubertal (10 boys, 16 girls), constitutional delay of puberty (CDP, 13 prepubertal boys >12 years), hypogonadotropic hypogonadism (HH, 5 prepubertal boys >12 years), central precocious puberty (CPP, 19 girls) or premature thelarche\/variant (13 girls). <i>Results:<\/i> Peak LH response was higher in prepubertal boys >12 years compared with younger boys (p < 0.01) but showed no further change in early puberty. CDP boys had LH responses similar to prepubertal boys >12 years. HH boys showed an absent LH response which diagnosed HH with 100% sensitivity and 96% specificity. Thelarche girls had LH:FSH peak ratios lower than normal prepubertal (p = 0.001), pubertal (p < 0.05) or CPP (p = 0.001) girls. <i>Conclusions:<\/i> We have established normative values for the low-dose GnRH test in children. The test successfully differentiated HH from CDP in boys, and contributed to the differential diagnosis of CPP and premature thelarche in girls.<\/jats:p>","DOI":"10.1159\/000080324","type":"journal-article","created":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T11:49:38Z","timestamp":1093607378000},"page":"168-176","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Utility of a Low-Dose Gonadotropin-Releasing Hormone Test in the Context of Puberty Disorders"],"prefix":"10.1159","volume":"62","author":[{"given":"H.","family":"Zevenhuijzen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.H.","family":"Kelnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.M.","family":"Crofton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-72-6-1229"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.76.1.26"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1490023"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2885%2980512-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-69-5-963"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.78.1.30"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000178795"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-71-5-1251"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.0.1230347"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000183870"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-49-1-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-66-1-131"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.6.1967"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-70-3-629"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.81.5.1798"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-72-6-1255"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-41-5-938"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1350399"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.12.3976"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0300-0664.2001.01448.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1995.tb01899.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.78.3.602"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.80.10.2980"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159%2F000185421"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2002.01520.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3109%2F09513599209015551"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-67-3-474"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159%2F000183950"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2895%2970492-2"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00446063"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2879%2980079-7"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.55.12.941"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2008-1058836"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:33:45Z","timestamp":1745465625000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2004,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080324","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2004]]}}}