{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:05:27Z","timestamp":1770505527992,"version":"3.49.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; C-reactive protein is considered a risk factor for coronary artery disease. In addition to its lipid-lowering properties, statin decreases the level of C-reactive protein. Abrupt cessation of statin therapy during treatment could increase the incidence of cardiac events in patients with atherosclerotic heart disease. The changes of C-reactive protein after withdrawal of statin therapy are still unknown. &lt;i&gt;Methods:&lt;\/i&gt; Twenty patients with hyperlipidemia received statin (atorvastatin, 10 mg\/day) therapy for 3 months. The levels of lipid profiles and C-reactive protein were assessed before receiving the statin therapy, immediately after 3 months of therapy, and on the 3 consecutive days after withdrawal of statin treatment. &lt;i&gt;Results:&lt;\/i&gt; After 3 months of statin therapy, the total cholesterol, low-density lipoprotein cholesterol (LDL-chol), and C-reactive protein were significantly reduced (264.94 \u00b1 16.23 vs. 183.44 \u00b1 16.34 mg\/dl, 183.17 \u00b1 34.56 vs. 122.00 \u00b1 17.66 mg\/dl, and 2,309.00 \u00b1 437.85 vs. 1,257.95 \u00b1 207.99 ng\/ml, respectively). The level of C-reactive protein increased on the second day after withdrawal of statin therapy (2,590.14 \u00b1 1,045.05 vs. 1,257.95 \u00b1 207.99 ng\/ml); however, the total cholesterol and LDL-chol did not increase during the 3-day period after withdrawal of statin therapy. &lt;i&gt;Conclusions:&lt;\/i&gt; The increase in the level of C-reactive protein after withdrawal of statin therapy may be a contributing factor to the increased incidence of cardiac events in patients who have abruptly stopped statin therapy.<\/jats:p>","DOI":"10.1159\/000080486","type":"journal-article","created":{"date-parts":[[2004,9,2]],"date-time":"2004-09-02T18:39:45Z","timestamp":1094150385000},"page":"166-170","source":"Crossref","is-referenced-by-count":35,"title":["Effect of Withdrawal of Statin on C-Reactive Protein"],"prefix":"10.1159","volume":"102","author":[{"given":"Kun-Tai","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ter","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Sheng","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Yu","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsueh-Wei","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Choi","family":"Voon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Hsiung","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114688"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199705013361802"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2Fhq1101.098486"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc2901.094094"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2801%2901924-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000070542.18001.87"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2802%2902953-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200010193431603"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa003147"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199408183310701"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2800%2900581-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200010193431602"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000012625.02748.62"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1373%2F49.4.666"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1067%2Fmhj.2003.34"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F01.HDX.0000050407.62572.DE"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000029743.68247.31"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2904480-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000012530.68333.C8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199704033361401"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs1101.098151"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.285.19.2481"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5699%2894%2990137-6"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-9877%2802%2900232-3"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:36:10Z","timestamp":1745465770000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080486","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}