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Oncogenes and tumour suppressor genes involved in other tumours do not appear to play a major role in the pathogenesis of pituitary tumours. In addition, germline genetic disorders in which pituitary tumours are a common feature have not shed much light on the more common sporadic tumour. A number of defects in specific feedback regulation in the secretory tumours have been identified, but it is presently unclear as to what extent these are a consequence of the tumour, possibly enhancing its growth or survival, rather than the cause. However, recent studies on the cell cycle have demonstrated significant abnormalities that have been traced to a cytoplasmic kinase which appears to be abnormally expressed in the majority of pituitary adenomas, and we are beginning to see a possible unifying abnormality.<\/jats:p>","DOI":"10.1159\/000080512","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T15:02:15Z","timestamp":1100271735000},"page":"117-123","source":"Crossref","is-referenced-by-count":2,"title":["Akting and Cycling: A Tale of the Pituitary"],"prefix":"10.1159","volume":"62","author":[{"given":"Ashley 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