{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:17:40Z","timestamp":1760782660189,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2004]]},"abstract":"<jats:p>ATM, the protein product of the gene mutated in the human autosomal recessive disorder ataxia telangiectasia, is involved in detection of double strand breaks (DSBs) and is a key component of the damage surveillance network of cell cycle proteins. In somatic cells ATM phosphorylates many other proteins including p53, an important regulator of cell cycle control. Mice deficient for &lt;i&gt;Atm&lt;\/i&gt; are male sterile with arrest and apoptosis occurring at testis epithelial stage IV, which in normal spermatocytes corresponds to mid-pachynema. Unlike the situation in somatic cells, we find no evidence that disruption of the &lt;i&gt;Trp53 (p53)&lt;\/i&gt; gene, or its down-stream target &lt;i&gt;Cdkn1a (p21\/Cip1)&lt;\/i&gt; results in even a partial rescue of the &lt;i&gt;Atm&lt;\/i&gt; defect. \u00a0\u00a0\u00a0<\/jats:p>","DOI":"10.1159\/000080603","type":"journal-article","created":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T06:36:52Z","timestamp":1097476612000},"page":"256-262","source":"Crossref","is-referenced-by-count":20,"title":["The mammalian mid-pachytene checkpoint: meiotic arrest in spermatocytes with a mutation in &lt;i&gt;Atm&lt;\/i&gt; alone or in combination with a &lt;i&gt;Trp53 (p53)&lt;\/i&gt; or &lt;i&gt;Cdkn1a (p21\/cip1)&lt;\/i&gt; mutation"],"prefix":"10.1159","volume":"107","author":[{"given":"T.","family":"Ashley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Westphal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Plug-de Maggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.G.","family":"de Rooij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,10,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s004120050422"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1674"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80086-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1677"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.2850"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000076812"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/5075"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13084"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/3882"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/35007091"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5395.1893"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.190030497"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s004120050241"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s004120050356"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/935"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80069-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5920"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5331.1497"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204252"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80070-2"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/80603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:36:56Z","timestamp":1745465816000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000080603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":20,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2004,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000080603","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"type":"print","value":"1424-8581"},{"type":"electronic","value":"1424-859X"}],"subject":[],"published":{"date-parts":[[2004]]}}}